Gene expression inference with deep learning[github][paper] This deals with a specific prediction task, namely to predict the expression of specified target genes from a panel of about 1,000 pre-selected “landmark genes”. As the authors explain, gene expression levels are often highly correlate...
c Performance of SpaDo when using cell type annotation from original paper or Seurat v4 with different value of parameter “Resolution” on osmFISH, seqFISH, and STARmap datasets. R resolution. d Performance of SpaDo when using different spot deconvolution methods. e Performance of SpaDo when ...
Supermeres are highly enriched with cargo involved in multiple cancers (glycolytic enzymes, TGFBI, miR-1246, MET, GPC1 and AGO2), Alzheimer’s disease (APP) and cardiovascular disease (ACE2, ACE and PCSK9). The majority of extracellular RNA is associated with supermeres rather than small ...
T-cell development provides an excellent model system for studying lineage commitment from a multipotent progenitor. The intrathymic development process has been thoroughly studied. The molecular circuitry controlling it has been dissected and the necess
Scheme 1 Schematic view of the nucleic acid extraction and HPV-Multiple RPA-CRISPR/Cas12a(H-MRC12a) typing assay Full size image At present, mature commercialized HPV point-of-care testing (POCT) products, such as HPV test strips, utilize principles related to cytology staining [6]. However,...
Explaining contrasting patterns of distribution between related species is crucial for understanding the dynamics of biodiversity. Despite instances where hybridization and whole genome duplication (WGD) can yield detrimental outcomes, a role in facilita
On the other hand, it is remarkable that two of the satellites studied in this paper (ClaSat02-6317 and ClaSat13-398), which appear to be dispersed according to BLAST and FISH results, are related to mobile elements and show homology of an important part of their sequences with such ele...
The data and code used for the validation are at github.com/andersen-lab/paper_2018_primalseq-ivar [77]. Oxford Nanopore sequencing and analysis Using the same PCR amplicons used for amplicon-based Illumina sequencing, we sequenced three replicates of the mixed Zika virus population (90% virus...
Note that this reward scheme is not intended to produce effects of the penalty on the participants’ probability estimates; instead, it incentivizes participants to veridically report the objective posterior at all levels of the posterior or penalty. The reward scheme and its implications were ...
Fig. 1: Daxx loss alters the chromatin landscape and transcription in LT-HSCs.a, Overview scheme of haematopoiesis. ST-HSC, short-term haematopoietic stem cells; MegE, megakaryocyte-erythrocyte; MEP, megakaryocyte-erythrocyte progenitor; GM, granulocyte-monocyte. b...