Biology of incretins: GLP-1 and GIP. Gastroenterology 2007; 132: 2131-2157 [PMID: 17498508]Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007; 132(6): 2131-57. Baggio, L. L. and Drucker, D. J. (2007). "Biology of incretins: GLP-1 and GIP....
J. Biology of incretins: GLP-1 and GIP. Gastroenterology 132, 2131–2157 (2007). Article CAS PubMed Google Scholar Antolin-Fontes, B. et al. The habenular G-protein-coupled receptor 151 regulates synaptic plasticity and nicotine intake. Proc. Natl Acad. Sci. USA 117, 5502–5509 (2020)...
Thus, the occurrence of a third somatostatin precursors (PSSII) has been initially established in anglerfish (Hobart et al., 1980) and later on in other species of fish including trout (Moore et al., 1995, 1999) and goldfish (Lin et al., 1999b). Most peptides derived from PSSII, ...
Other recent work highlights the importance of α-cell-produced proglucagon-derived peptides, incretin hormones from the gastrointestinal tract and other dietary components, including certain amino acids and fatty acids, in priming and potentiation of the β-cell glucose response. These advances provide...
GASTROENTEROLOGY 2007;132:2131–2157 Biology of Incretins: GLP-1 and GIP LAURIE L. BAGGIO and DANIEL J. DRUCKER Department of Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada Daniel J. Drucker,...
Furthermore, GLP-1, unlike GIP, potently stimulates insulin secretion and reduces blood glucose in human subjects with type 2 diabetes. This article summarizes current concepts of incretin action and highlights the potential therapeutic utility of GLP-1 receptor agonists and dipeptidyl peptidase-4 (...
Incretin hormones, principally glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1(GLP-1), potentiate meal-stimulated insulin secretion through direct (GIP + GLP-1) and indirect (GLP-1) actions on islet 尾-cells. GIP and GLP-1 also regulate glucagon secretion, through ...
In contrast to GIP, GLP-1 retains its insulinotropic effect in type 2 diabetic patients and a long-acting agonist of this peptide is now used for the treatment of this disease. Both peptides, however, have also long-term beneficial effect on the preservation or augmentation of the pancreatic...
Although DPP-4 cleaves dozens of regulatory peptides and chemokines in vitro, studies of mice with genetic inactivation of incretin receptors demonstrate that GIP and GLP-1 receptor dependent pathways represent the dominant mechanisms transducing the glucoregulatory actions of DPP-...
In contrast, GIP is released from intestinal K-cells that are localized to more proximal regions (duodenum and jejunum) of the small intestine. However, endocrine cells that produce GLP-1 or GIP, as well as cells that produce both peptides, can be found throughout all regions of the ...