Combined, this review will be useful for any scientist who wishes to explore new biomimetic approaches to influence cell fate by engineering the microenvironment. 2. A physical model of cadherins One way of generating advanced biomaterials that can influence cell behavior is to incorporate a ...
Journal of Structural Biology – Paper of the Year 2020doi:10.1016/j.jsb.2021.107734Thomas BraunElsevier BVJournal of Structural Biology
Combined transcriptomics and metabolomics analysis of the flavonoid synthesis pathway In this study, DEGs and DAMs significantly related to flavonoid synthesis were identified. The subsequent analysis of these DEGs and DAMs confirmed that 105 DEGs and 70 related metabolites were associated with flavonoid ...
The ongoing clinical trial utilizing JSP191 combined with low-dose radiation is led byLori Muffly, MD, assistant professor of blood and marrow transplantation and cellular therapies. The preliminary results are encouraging based on the first six participants, who were older adults (64–74 years old...
Higher levels of mucin 2 were detected in proximal colon tissues of human REG3Atg mice (Fig. 1h). Ki67 cells in the colon crypt also remarkably increased in these REG3A tg mice (Fig. 1i). The Cdkn1a (p21) and Cdkn2d (p19) were downregulated in the colonic epithelial cells (Fig. 1...
In the sensitivity test of SpaDo combined with spot deconvolution methods, we benchmarked Cell2location against RCTD and SPOTlight. For Cell2location, the single-cell regression model was trained with default parameters and the Cell2location model was obtained with parameter detection_alpha = 20...
Combined Positive Score (CPS) of PD-L1 expression, which is an approved biomarker of immunotherapy response, was also significantly associated objective response (Supplementary Fig.20). However, the predictive accuracy for CPS was quite modest (AUC: 0.646 (95% CI 0.580–0.713); Fig.8C, D). ...
“IDH,” in order to examine the overall effects of mutations in bothIDH1andIDH2. AUC values of the target metabolites in these four MG pairs also appeared to be mostly higher than AUC values of 60 metabolites detected in the metabolome data (Fig.3d). Evaluation of the empirical statistical...
We aimed to identify the prevalence and emerging status of multidrug-resistant bacteria and fungi and their associated mortality in nine countries in the Arabian Peninsula. Original research articles and case studies regarding multidrug-resistant bacteri
1e). Clusters V and VI are both enriched in LaminB1, are late replicating and have intermediate CpG methylation, consistent with the B1 subcompartment label, so we combined them to form an IPG termed B1 (Fig. 1d). Clusters VII and VIII are both enriched in Protect-seq signal, are late...