In this paper, Mutlu et al. identifies a STING degrader, AK59, which inhibits downstream cGAS/STING activity through STING degradation employing a HECT-domain E3 ligase HERC4 and proteasomal ubiquitination pathway. Merve Mutlu Isabel Schmidt Danilo Guerini ArticleOpen Access29 May 2024 Nature Comm...
Read the latestBehind the Paperarticles here: Cones, sticks and croissants: Early cephalopod evolution Alexander Pohle Published Apr 14 2022 Tentacular team up: Deep partnerships between sea anemones and bacteria Shana Goffredi Published Jan 18 2021 ...
we used the Tg(gata2b:Gal4sd32) line and created theUAS:miR-128plasmid, while forfli1aexpression we createdfli1a:miR-128plasmid. One-cell-state embryo was injected with tol2 mRNA and the indicated plasmids, and WISH was
c Performance of SpaDo when using cell type annotation from original paper or Seurat v4 with different value of parameter “Resolution” on osmFISH, seqFISH, and STARmap datasets. R resolution. d Performance of SpaDo when using different spot deconvolution methods. e Performance of SpaDo when ...
” The paper retrieval showed that the previous studies on gliomas appeared to be largely focused on four target genes (CIC,EGFR,IDH1, andTP53), all cancer driver genes [45], among the 13 target genes (Fig.5b). This overall pattern was also observed in papers on various cancers in ...
The molecular basis of IGF-II/IGF2R recognition: a combined molecular dynamics simulation, free-energy calculation and computational alanine scanning study Insulin-like growth factor-II (IGF-II) is a key regulator of cell growth, survival, migration and differentiation, and is thus pivotal in many...
SGS has the advantages of low cost, high accuracy and short sequencing time, but shorter sequence read lengths; TGS has longer sequence reads but higher error rates [47]. As a result, more and more studies on the response to plant stress are now beginning to make use of combined SGS and...
Cisplatinum and 5-FU combined with radiotherapy and surgery in the treatment of squamous cell carcinoma of the oesophagus: palliative effects and tumour ... C Mercke,M Albertsson,G Hambraeus,... - 《Acta Radiologica Therapy Physics Biology》 被引量: 59发表: 1991年 Results of Hyperthermia Alone...
Finally, a major advantage of our fundamental concept is that both robustness and resilience can be represented by means of system functionality as a function of time and can thus be both compared and combined with each other. 1.1.1. Lifespan as a Longevity Measure in Plants The longevity of...
We highlight in this paper specifically location-sensitive units and head-body angle-sensitive units. We selected for display in the paper exemplary units that had prominent random effects, and then used 1-way ANOVA to confirm the significance of the dependences of firing rates on the variable ...