We illustrate a proposed model of control of NO formation whereby at low concentrations of 4-HNE a negative feedback loop maintains a constant level of NO production with an observed inflection at approximately 1聽碌M, while at higher 4-HNE concentrations positive feedback is observed. Further,...
铁蛋白通过Msr1引发中性粒细胞胞外捕集器介导的细胞因子风暴,有助于成年发病的斯蒂尔病的发病机制。 353.An mTORC1-mediated negative feedback loop constrains amino acid-induced FLCN-Rag activation in renal cells with TSC2 loss. mTORC1介导的负反馈回路制约了TSC2缺失的肾细胞中氨基酸诱导的FLCN-Rag激活。
PC Evans.NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling.Journal of Biological ... K Enesa,M Zakkar,H Chaudhury,... - 《Journal of Biological Chemistry》 被引量: 0发表: 2008年 加载更多来源...
It is known that the presence of a positive feedback loop is a necessary condition for a system to exhibit multi-stationarity; and a negative feedback loop is a necessary condition for it to have a point or oscillatory attractor. Broadly speaking, the wide variety of bistable switches found ...
In that case, the negative feedback loop can be impaired, leading to an excessive increase in corticosteroids’ levels with several physiological changes [56]. Exacerbated and chronic activation of the HPA axis and the immune system are responsible for several psychiatric disorders, such as anxiety...
procedure can also be carried out with the constraint that inputIshould act only on the output node\({g}_{1}\): deleting the link fromIto\({g}_{2}\)at the very beginning. The incoherent feed-forward structure is now impossible, and the minimum negative feedback loop emerges (Fig.2d...
components, the original system being a “negative feedback” loop around an otherwise consistent system. In this interpretation, the number of interconnec- tions among monotone components corresponds to the number of variables be- ing fed-back. In addition, and independently from the theory develop...
negative feedback loop of a monotone controlled system. In the Appendix II we provide a proof of existence and uniqueness for controlled delay systems, including the semiflow property. 2. Preliminaries. Let B be a real Banach space, and let K ⊆ B be a cone, that ...
The cell cycle model contains many negative feedback loops, hence is not causally consistent, preventing the use of [23]. Leading nodes interpretation While the cell cycle subnetwork encompasses all phases of the cell cycle, the leading node analysis (Table 5) were used to identify the key ...
Incoherent Feedforward Control Governs Adaptation of Activated Ras in a Eukaryotic Chemotaxis Pathway Adaptation in signaling systems, during which the output returns to a fixed baseline after a change in the input, often involves negative feedback loops an... K Takeda,D Shao,M Adler,... - 《...