Assembly of Genetically Engineered Ionizable Protein Nanocage-based Nanozymes for Intracellular Superoxide Scavenging Nanozymes are promising for treating various diseases by regulating cytotoxic free radicals, but their specific enzyme-mimicking activities for mediating intracellular free radicals have been limite...
Catalytic activities or signal transduction processes generally accompany changes in the secondary, tertiary, or quaternary structure [1]. If these changes occur distal from the chromophore, it is quite difficult to detect the changes in dynamics. Second, intermolecular interactions including protein–...
A series of coordinated actions of groups of protein interactions in molecular assemblies or pathways result in various cellular functions [1]. A proper understanding of PPI can help unveil PPI mechanisms and gain insight into the nature of cellular activities. Despite a wealth of available PPI ...
It could exert immunomodulatory effects through mitogen-activated protein kinases (MAPK) signaling pathway (Bai et al., 2020). Herbal oligosaccharide sources and specific biological activities are shown in Table 3. Table 3. Bioactive effects of herbal oligosaccharides. Chinese herbal medicineSource...
pneumoniae is a 591 amino acid multifunctional protein called Community Acquired Respiratory Distress Syndrome (CARDS) toxin. The amino terminal region of CARDS toxin (N-CARDS) retains ADP-ribosylating activity and the carboxy region (C-CARDS) contains the receptor binding and vacuolating activities. ...
C-Reactive Protein BMI: Body Mass Index HEI: Healthy Eating Index ANOVA: Analysis of Variance RCS: Restricted Cubic Spline ROS: Reactive Oxygen Species GLUT4: Glucose Transporter Type 4 References Aguayo-Mazzucato, C. et al. Acceleration of β cell aging determines diabetes and Senolysi...
Biological functions of glycosylation. Glycosylation has a variety of biological functions that can affect protein folding and stability, for example,O-GlcNAcylation accelerates protein degradation in cells and decreases protein stability, it also regulates activities such as protein aggregation and phase sep...
(AECOM, 2016). WF sites sourcing water from rivers or dams may expose workers towaterborne diseases, such asleptospirosis, through contact with droplet aerosols generated during work activities that usecontaminated water(RenewableUK, 2015). Moreover, offshore WF workers may need to dive to ...
The maintenance and transition of cellular states are controlled by biological processes. Here we present a gene set-based transformation of single cell RNA-Seq data into biological process activities that provides a robust description of cellular states
Specifically, we investigated whether the inferred GMV activities for held-out cells were conveying the same biological information as to when this population is seen at the time of training. To this end, we removed one cell type of the stimulated condition during training, and then inferred the...