One elegant solution: a "dilution series" type of experiment where a solution with the element to study is diluted in another solution at different concentrations.This is exactly what Dilon et al. did in their publication "Targeted RNA-sequencing for the quantification of measurable residual ...
18. Suresh A, Verma C: Modelling study of dimerization in mam- malian defensins. BMC Bioinformatics 2006, 7(Suppl 5):S17. 19. Thadani R, Tammi MT: MicroTar: predicting microRNA targets from RNA duplexes. BMC Bioinformatics 2006, 7(Suppl 5):S21. 20. Takasaki S, Kawamura Y, Konagaya...
The study provides a comprehensive transcriptomic atlas of the human gastrointestinal tract across the lifespan, highlighting inflammation-induced changes in epithelial stem cells that alter mucosal architecture and promote further inflammation. Amanda J. Oliver ...
News & Views10 Feb 2025Nature Reviews Clinical Oncology P: 1-2 Unveiling heterogeneity in rare cells by combining RNA-based sorting and scRNA-seq A study describes the development of PERFF-seq, a method to ‘FISH’ out rare cells using RNA markers, helping to solve the challenge in single...
Bioinformatics is the study of DNA, RNA, andprotein sequenceswith the help of computational software. It focuses on the sequences themselves, rather than the structures that they form. Several online sequence databases serve as sources of reference sequences, as well as aggregators of user-submit...
Such an approach was applied in a cell cycle study in Schizosaccharomyces pombe, where Rustici et al. showed that the presence or absence of consensus binding sites in the promoter regions corresponds to the cyclic expression pattern of the genes [8]. Genes with a peak expression at similar ...
Conclusion: This study shows the conservation of DNA-contact residues in DNA-binding domains. We conclude that the members in the same subfamily bind DNA specifically and the members in different subfamilies often recognize different DNA targets. Additionally, we observe the co-evolution of DNA-...
The concepts above will be introduced with the help of a case study, which means that you will be able to apply everything you learned to an actual real-world dataset. Step 4: Statistics After learning probability, you can take this course to learn the fundamentals of statistical inference ...
Case study 2: developing pathway-pathway similarity networks from heterogeneous data sources Using the advanced HPD search function online, a user can specify multiple proteins as the query input to obtain a list of most relevant pathways related to the query pro- tein set. For example, if the...
Detection of appropriate receptor proteins and drug agents are equally important in the case of drug discovery and development for any disease. In this study, an attempt was made to explore colorectal cancer (CRC) causing molecular signatures as receptor