Binding assays represent another tool to identify markers that might be used to diagnose or treat diseases. Since peptide libraries contain hundreds of peptide combinations, combining these peptides with cells or proteins can provide information on both structure-activity relationships or targets for ther...
Synthetic DNA oligonucleotides, known as aptamers, have been increasingly used for affinity binding assays to proteins, as well as for separation studies and as biosensors. Recent advances have been made in protein–DNA binding assays using capillary electrophoresis, laser-induced fluorescence, ...
Assays for Penicillin – Binding Proteins (PBPs) *ELSEVIERThe Biology of Beta-Lactam Antibiotics
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This work describes validation of exoribonuclease XRN1 as a selective oncology target and development of a suite of assays to support XRN1 drug development, including a human crystal structure of XRN1 bound to adenosine-3’,5’-bisphosphate (pAp). ...
The design of proteins that bind to a specific site on the surface of a target protein using no information other than the three-dimensional structure of the target remains a challenge1–5. Here we describe a general solution to this problem that starts
leading to the phosphorylation of particular cellular proteins and subsequent initiation of a multitude of cellular responses. Binding and hydrolysis of nucleotides plays a major role in these activities, and our nucleotide analogs and assa...
The detailed understanding of the binding of small molecules to proteins is the key for the development of novel drugs or to increase the acceptance of substrates by enzymes. Nowadays, computer-aided design of protein–ligand binding is an important tool
Biotherapeutic:A class of therapeutic macromolecular compounds, most often proteins and peptides, produced using biotechnology such as recombinant DNA technology. Ligand-binding assays:Analytical methods that frequently use assay reagents with high binding affinity for a target analyte in order to specifica...
RNA-binding proteins (RBPs) modulate all aspects of RNA metabolism, but a comprehensive picture of RBP expression across tissues is lacking. Here, we describe our development of the method we call HARD-AP that robustly retrieves RBPs and tightly associat