steatorrhea, therapeutics, deficiency, fat absorption, dogs, weight losses, case studies, diarrhea, zinc, bile salts, skin diseases, CampylobacterTwo dogs were presented with chronic diarrhoea, weight loss and skin problems. In each case investigation revealed persistent steatorrhoea due to a failure...
Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport Hepatology, 44 (2006), pp. 195-204 Google Scholar 37 E. van de Steeg, E. Wagenaar, C.M. van der Kruijssen, J.E. Burggraaff, D.R. de Waart, R.P. Elf...
Bile flow and biliary secretion rates of bile salts, cholesterol and phospholipids were similar in Fxr-/- and control mice. The composition of the biliary bile salt pool was altered in Fxr-/- mice, however, characterized by increased hydrophobicity (cholic acid-muricholic acid ratio: 1.5 (0.93...
The name “bile acid” transporters is misleading because at physiological pH in blood and in the lumen of the ileum, bile acids are in the anionic form and actually are bile salts. Regarding transport, we will use the term bile salt (BS). Furthermore, the family name needs to be ...
In humans, the ASBT inhibitor odevixibat has shown promising results in alleviating pruritus symptoms and decreasing serum BA in a phase 3 trial of cholestatic liver diseases 156 . In contrast, the use of an ASBT inhibitor SHP626 (volixibat) has shown limited therapeutic benefits in patients ...
A general introduction to bile salts Bile acids (BA) are essential for the absorption of dietary lipids and fat-soluble vitamins and also act as signaling molecules for diverse endocrine and paracrine functions (Keitel et al. 2008). Besides others, they can activate different BA receptors, such...
Patients with anxiety disorders often have other neuropsychiatric disorders, such as depression, and functional impairment of emotional and behavioural symptoms may occur across the lifespan3. The aetiology of anxiety disorders is complicated, and recent studies have reported that several risk factors, ...
Recently, the variation of BA metabolites in the diseased brains also illustrates that BA correlate with the pathogenesis of various neurological diseases (Table 1), or act as neuro- protective factors to improve symptoms in some neuro- logical diseases (Table 2). Altered BA metabolites in...
Phosphatidylcholine, the predominant phospholipid in bile, is washed from the canalicular membrane by bile salts. In contrast to PFIC type 2, in PFIC type 3 bile salt transport proceeds unimpaired, but this occurs without phospholipids because of the MDR3 deficiency. This has major pathophysiologic ...
of bile acids causesmalabsorptionof fat and fat-soluble vitamins, which will lead to the development of vitamin K–dependentcoagulopathy,neurologic symptomsdue to vitamin E deficiency, and bone disease from low levels of vitamin D; there may also be malnutrition and secondary symptoms. ...