Methods A systematic search of the English language literature of chronic diarrhoea was performed focused on three possible aetiologies of diarrhoea: small intestinal bacterial overgrowth (SIBO), idiopathic bile salt malabsorption (IBAM), gluten responsive enteropathy. Results Recent studies suggest that ...
Acute effects of abdominopelvic irradiation on the orocecal transit time: its relation to clinical symptoms, and bile salt and lactose malabsorption. Twenty-five patients with abdominopelvic malignant tumors receiving irradiation were studied. The following items were assessed before, during, and at ...
It has been suggested that, because of bile-salt malabsorption, patients with ileal dysfunction " spill " glycine-conjugated bile-salts into their large bo... R Hermon Dowling,GA Rose,D June Sutor - 《Lancet》 被引量: 177发表: 1971年 Jejunal bacteriology and bile-salt metabolism in patients...
Clinically, symptoms of cholestasis include pruritus, dark urine, pale stools, and steatorrhea. Like bilirubin, other substances normally excreted in bile, such as gamma-glutamyl transferase, alkaline phosphatase, and cholesterol, accumulate in the blood. Fat malabsorption may lead to deficiencies of vi...
bile salt concentrations with an increase in both the glycine/taurine ratio and dihydroxy bile salts. The latter produces toxic, hydrophobic bile acids that lower the critical micellar concentration (CMC) and further exacerbates malabsorption. In well nourished patients, however, control of steatorr...
The clinical symptoms of such inborn errors are heterogeneous. Patients may present with cholestasis, malabsorption of lipids and vitamins, fibrosis, neurological disease, or hypercholesterolemia, and if untreated, progressive liver disease may result in high morbidity rates (Heubi et al., 2007). ...
Define Bile acid sequestrant. Bile acid sequestrant synonyms, Bile acid sequestrant pronunciation, Bile acid sequestrant translation, English dictionary definition of Bile acid sequestrant. n. A chemical that promotes sequestration. American Heritage®
Synthetic pathways of bile acids and enterohepatic bile acid circulation. LDL, low-density lipoprotein; LDLR, low-density lipoprotein receptor; NTCP, Na + -dependent taurocholic acid co-transporting polypeptide; OATP, organic anion-transporting polypeptides; BSEP, bile salt export pump; ASBT, apic...
EFA deficiency in mice disturbs fat malabsorption via unidentified mechanisms, presumably at the level of the intestinal mucosa. The farnesoid X receptor (FXR) is involved in the regulation of bile salt homeostasis in the enterohepatic circulation. We addressed the role of FXR in fat absorption and...
secondary BAs, is the most quantitatively important and complex microbial bile salt transformation5,6,7,8. BA act as signalling molecules through activation of receptors: farnesoid X receptor (FXR) is most potently stimulated by CDCA, and the secondary BAs stimulate TGR5 (also known as G-protein...