Here, they produce Cl- secretion by a calcium- and cyclic AMP-dependent mechanism, resulting in diarrhea. Cholestasis may lead to serum bile acid concentrations high enough to produce colonic secretion by serosal surface effects. When resection or disease interferes with ileal function, the ...
A Clostridia-rich microbiota enhances bile acid excretion in diarrhea-predominant irritable bowel syndrome. J. Clin. Invest. 130, 438–450 (2020). Article CAS PubMed Google Scholar Bárcena, C. et al. Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice. Nat...
actions in the colon. They are preferentially (95%) absorbed in the terminal ileum through enterohepatic circulation. Bile acid malabsorption or bile acid diarrhea occurs when reabsorption is impaired due to ileal disease or ileal resection and bile acidss stimulate water secretion and intestinal ...
Bile acidsequestrants are positively charged polymeric resins that bindbile acidsin the intestinal lumen to decrease the aqueous concentration and the efficiency of intestinal conservation of bile acids. In patients with mildbile acidmalabsorption,bile acid sequestrantsreduce diarrhea by lowering the concen...
Sign up with one click: Facebook Twitter Google Share on Facebook sequestrant (redirected fromBile acid sequestrant) Medical Acronyms Wikipedia se·ques·trant (sĭ-kwĕs′trənt) n. A chemical that promotes sequestration. American Heritage® Dictionary of the English Language, Fifth Edition...
coated with a polymer so as to allow the release thereof around the lower part of the small intestine and the cecum; and medicines (for example, antilipemics) comprising a combination of bile acid re-absorption inhibitors with the above-described preparations for preventing bile acid diarrhea.do...
The gut microbiota-bile acid axis as a target for CLD treatment FXR ligands Current studies have provided substantial evidence that multiple FXR agonists could ameliorate the gut microbiota, suppress BA synthesis and metabolism, and relieve liver fibrosis progression in animal models with cholestasis (...
Bile Acid Malabsorption Caused by Ileal Resection Two syndromes of bile acid malabsorption caused by ileal resection—bile acid diarrhea (cholerheic diarrhea) and fatty acid diarrhea (steatorrheic diarrhea)—have been identified, characterized, and symptomatic therapy has been developed... AF Hofmann ...
23 In a few patients, the movement of the bile acid pool to the distal intestine seems to overwhelm the ileal transport system, and bile acid malabsorption occurs. This is clinically manifest as diarrhea and generally responds to administration of a bile acid sequestrant. Ileal Resection ...
Diarrhea: Impaired feedback inhibition of bile acid synthesis associated with bile acid diarrheaPurpose: Intensity modulated radiation therapy (IMRT) is a significant therapeutic advance in prostate cancer, allowing increased tumor dose delivery and increased sparing of normal tissues. IMRT planning uses ...