Here, they produce Cl- secretion by a calcium- and cyclic AMP-dependent mechanism, resulting in diarrhea. Cholestasis may lead to serum bile acid concentrations high enough to produce colonic secretion by serosal surface effects. When resection or disease interferes with ileal function, the ...
Because of the importance of these receptors, agonists of TGR5 and intestine-specific FXR agonists are currently being tested as an option for the treatment of diabetes mellitus and primary bile acid diarrhea, respectively. This review summarizes current knowledge of the functional roles of bile acid...
23 In a few patients, the movement of the bile acid pool to the distal intestine seems to overwhelm the ileal transport system, and bile acid malabsorption occurs. This is clinically manifest as diarrhea and generally responds to administration of a bile acid sequestrant. Ileal Resection ...
This suggests that reduced FGF19 levels may be the primary cause for excessive bile acid synthesis that exceeds the normal capacity for ileal reabsorption, producing bile acid diarrhea. Thus, FXR agonists or FGF19 itself could be used therapeutically to interrupt the cycle of excessive bile acid ...
approximately 40% of CLD patients are insensitive or irresponsive to UDCA treatment. Besides, no clear-cut survival benefit with UDCA in CLD has been displayed (Beuers et al.2015; Cheung et al.2019). 24-Norursodeoxycholid acid (norUDCA), a side chain shortened homolog of UDCA, presents se...
Synthetic pathways of bile acids and enterohepatic bile acid circulation. LDL, low-density lipoprotein; LDLR, low-density lipoprotein receptor; NTCP, Na + -dependent taurocholic acid co-transporting polypeptide; OATP, organic anion-transporting polypeptides; BSEP, bile salt export pump; ASBT, apic...
A Clostridia-rich microbiota enhances bile acid excretion in diarrhea-predominant irritable bowel syndrome. J. Clin. Invest. 130, 438–450 (2020). Article CAS PubMed Google Scholar Bárcena, C. et al. Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice. Nat...
coated with a polymer so as to allow the release thereof around the lower part of the small intestine and the cecum; and medicines (for example, antilipemics) comprising a combination of bile acid re-absorption inhibitors with the above-described preparations for preventing bile acid diarrhea.do...
glycosylation in the trans-Golgi network travels through the subapical compartment to the canalicular membrane where it mediates the transport of conjugated bile acids (cholic and chenodeoxycholic acid). Another apical ABC transporter is multi-drug resistance protein 3 (MDR3) (ABCB4), a flippase of...
Diarrhea: Impaired feedback inhibition of bile acid synthesis associated with bile acid diarrheaPurpose: Intensity modulated radiation therapy (IMRT) is a significant therapeutic advance in prostate cancer, allowing increased tumor dose delivery and increased sparing of normal tissues. IMRT planning uses ...