Diet1 modulates intestinal production of the hormone fibroblast growth factor 15 (FGF15), which signals in liver to regulate bile acid synthesis. C57BL/6ByJ mice with a spontaneous Diet1 null mutation are resistant to hypercholesterolemia compared to wild-type C57BL/6J mice through enhanced cholest...
Diet1, bile acid diarrhea, and FGF15/19: mouse model and human genetic variants - ScienceDirectintestinefibroblast growth factor 15/19Hybrid Mouse Diversity PanelDiet1 modulates intestinal production of the hormodoi:10.1194/JLR.M078279Jessica M. Lee *...
bile acid如何读 英:[baɪl ˈæsid] 美:[baɪl ˈæsɪd] bile acid是什么意思 胆汁酸 bile acid英英释义 noun any of several steroid acids (such as cholic acid) that occur in bile especially in the form of bile salts, are produced chiefly in the liver from cholesterol, and ...
A similar bile acid diarrhea and steatorrhea are also found after ileal resection surgery. In patients, terminal ileal resection causes a reduction in ASBT, resulting in a reduction in the absorption of bile acids. Shorter length ileal resection causes diarrhea, whereas resections greater than 100 ...
Over the last two decades, bile acids have been recognized as pivotal signaling molecules in NASH pathogenesis that enable fine-tuned gut-liver communication from the liver, the site of bile acid production, to the intestine, the site of nutrition sensing, to virtually throughout the body, where...
Bile acid diarrhoea (BAD) is a common disorder resulting from increased loss of bile acids (BAs), overlapping irritable bowel syndrome with diarrhoea (IBS-D). The gut microbiota metabolises primary BAs to secondary BAs, with differing impacts on metabolism and homeostasis. The aim of this study...
Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasti... Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced ...
Bile acid (BA)-activated nuclear receptors maintain BA homeostasis by regulating BA metabolism and transport within the enterohepatic circulation. BAs and their nuclear and G protein-coupled receptors also control lipid and/or glucose and energy homeostasis, inflammation and fibrosis as well as cell pr...
Patients with more severe bile acid malabsorption have both diarrhea and steatorrhea. Treatment with cholestyramine is of no benefit in this group of patients and may, in fact, worsen steatorrhea. These patients are best treated with a low-fat diet supplemented with medium-chain triglycerides. 展开...
In this Review, we highlight how the bile acid pool is manipulated by the gut microbiota, how it is dependent on the metabolic capacity of the bacterial community and how external factors, such as antibiotics and diet, shape bile acid composition. It is increasingly important to understand how...