While FXR and GPBAR1 are essential bile acid sensors that integrate the de novo bile acid synthesis with intestinal microbiota and liver metabolism, in a broader sense, BARs play a pathogenic role in the development of common human alignments including liver, intestinal and metabolic disorders, ...
Bile acid (BA)-activated nuclear receptors maintain BA homeostasis by regulating BA metabolism and transport within the enterohepatic circulation. BAs and their nuclear and G protein-coupled receptors also control lipid and/or glucose and energy homeostasis, inflammation and fibrosis as well as cell pr...
Despite decades of bile acid research, diverse biological roles for bile acids have been discovered recently due to developments in understanding the human microbiota. As additional bacterial enzymes are characterized, and the tools used for identifying new bile acids become increasingly more sensitive, ...
The profiles of bile acids and gut microbiota influence each other; bile acids can modulate microbiota composition, which in turn regulates the size and composition of the bile acid pool Disruption of bile acid–microbiota crosstalk promotes inflammation and a gastrointestinal disease phenotype, which ...
Through multiple in vivo experimental approaches in mice, together with a patient study, this work brings some new light on the relationships between biliary homeostasis, gallbladder function, and liver protection. We showed that hepatic bile acid composition is crucial for optimal liver repair, not...
Bile acid (BA) receptors (e.g., farnesoid X-activated receptor, muscarinic receptor) are expressed in cardiomyocytes, endothelial cells, and vascular smooth muscle cells, indicating the relevance of BAs to cardiovascular disease (CVD). Hydrophobic BAs are cardiotoxic, while hydrophilic BAs are cardi...
Distribution of bile acid transporters and receptors in the human gut and their potential involvement in type 2 diabetes (T2D) pathophysiology remain unknown. Objective We explored the expression of genes involved in bile acid metabolism throughout the intestines of patients with T2D and matched ...
Nuclear Receptors Regulate Bile Acid Synthesisnuclear receptors and bile acid synthesis regulationcholesterol homeostasis and bile acid synthesis feedback regulationhepatic microsomal enzyme cholesterol 7α‐hydroxylase (CYP7A1dietary cholesterol effect on regulation of classic (CYP7A1...
Recent studies have demonstrated that some natural bile acids and their derivatives promote the development of NASH, while others have therapeutic effects on NASH [15,17]. Several small molecules targeting bile acid metabolism, transport or bile acid receptors have been undergoing clinical trials for ...
By using the SMMC7721 and BEL-7402 cells, we showed that chenodeoxycholic acid (CDCA) and deoxycholic acid (DCA) stimulate hepatic SPX gene expression by activating TGR5 and FXR receptors through adenylate cyclase (AC)/cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) and mitogen-...