Ghosh AK, Bilcer G, Hong L, Koelsch G, and Tang J (2007) Memapsin 2 (beta- secretase) inhibitor drug, between fantasy and reality. Curr Alzheimer Res 4:418 - 422.Gosh, A.K.; Bilcer, G.; Hong, L.; Koelsch, G.; Tang, J. Memapsin 2 (beta secretase) inhibitor drug, between ...
Among various ways of reducing -amyloid production, the inhibition of -secretase (memapsin 2, BACE) is particularly attractive. Not only does -secretase initiates the amyloid cascade, it also is an aspartic protease, a class of proteases for which successful inhibitor drugs have been developed to...
BETA-SECRETASE INHIBITOR 2 英文别名: KTEEISEVN-STA-VAEF-NH2;BETA-SECRETASE INHIBITOR 2;KTEEISEVN-Sta-VAEF-NH2(Sta=Statine);H-LYS-THR-GLU-GLU-ILE-SER-GLU-VAL-ASN-STA-VAL-ALA-GLU-PHE-NH2 中文名: 中文别名: CBNumber: CB6364388
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The present invention relates to novel hydroxyethylamine compounds having Asp2 (β-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated β-amyloid levels or β-amyloid...
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Tang, Memapsin 2 (beta-secretase) inhibitors: drug development. Curr Alzheimer Res, 2008. 5(2): p. 121-31.Ghosh A. K. , Kumaragurubaran N. , Hong L. , Keolsh G. and Tang J. ( 2008 ) Memapsin 2 (beta-secretase) inhibitors: drug development . Curr. Alzheimer Res. 5 , 121 –...
Characterization of the human beta-secretase 2 (BACE2) 5'-Flanking region: identification of a 268-bp region as the basal BACE2 promoter. J. Mol. Neurosci. 2006; 29:81-99. [PubMed: 16757812]Maloney B, Ge YW, Greig NH, Lahiri DK: Characterization of the human -secretase 2 (BACE2)...
Fung, Kar-MingJames, JudithTang, JordanElsevier Inc.Alzheimers & DementiaChang et al., " P2-323: Memapsin 2 (beta-secretase, BACE) immunization as specific and safe therapy for Alzheimer's disease, " Alzheimer's & Dementia: Journal of the Alzheimer's Association, 4: T467, 2008....