XX Yan,K Xiong,XG Luo,RG Struble,RW Clough.Beta-secretase expression in normal and functionally deprived rat olfactory bulbs: inverse correlation with oxidative metabolic activity. Journal of Comparative Neurology . 2007Yan XX, Xiong K, Luo XG, Struble RG, Clough RW (2007) β-Secretase ...
英文名字 Active Recombinant Human beta-Secretase 1 - BACE-1 供应商 Biovision 产品货号 7609-1000 产品报价 ¥已停产 产品说明书 点击查看 购买方式 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868. 产品新闻
被引量: 6 摘要: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a β-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.收藏...
This fragment, the result of β-secretase cleavage, is important for AD pathology because it is cleaved by γ-secretase to release Aβ. A causative role of oxidative stress and light exposure in the pathogenesis of AMD and other retinal degeneration has also been proposed [5...
Beta-secretase BACE1 is differentially controlled through muscarinic acetylcholine receptor signaling. T. Zuchner, J.R. Perez-Polo, R. Schliebs, Beta-secretase BACE1 is differentially controlled through muscarinic acetylcholine receptor signaling, J. ... T Züchner,J Regino Perez-Polo,R Schliebs -...
The presenilin C-terminus is required for ER-retention, nicastrin-binding and γ-secretase activity gamma-Secretase is an intramembrane cleaving protease involved in Alzheimer's disease. gamma-Secretase occurs as a high molecular weight complex composed o... C Kaether,A Capell,D Edbauer,... - ...
Selenomethionine reduces the deposition of beta-amyloid plaques by modulating β-secretase and enhancing selenoenzymatic activity in a mouse model of Alzheimer's disease Alzheimer's disease (AD) is characterized by the production of large amounts of beta-amyloid (Aβ) and the accumulation of extrace...
We demonstrated that proBTC is cleaved by ADAM10 to produce BTC-CTF, which then undergoes intramembrane processing by presenilin-1- and/or presenilin-2-dependent γ-secretase to generate an intracellular-domain fragment (BTC-ICD). We found that the proBTC cytoplasmic domain is palmitoylated and ...
it is more descriptive and in accordance with IUBMB nomenclature. The original name of beta-secretase remains the most descriptive for function and can be used to describe activity against the APP substrate as well as the enzyme. However, it is important to note that beta-secretase may exist ...
Under conditions of chronic hypoxia, the expression of ADAM10, which is a candidate protein for α-secretase, is decreased in neuronal cells3. Additionally, hypoxia increases the BACE-1 level and the enzymatic activity of this protein by enhancing hypoxia-inducible factor 1α (HIF-1-α) ...