A less common plasmid-encoded class A β-lactamase is SHV-1. This enzyme shares about 60% identity with TEM-1 and has a similar substrate profile. It also has been a precursor of ESBLs and started to mutate. The pivotal mutation was an alteration at codon 238 converting glycine to serine...
They obtain the 1,2,4-triazole-3-thione compounds by their basic treatment. By connecting (113) to O-trityl-hydroxylamine through trityl elimination in an acidic environment, hydroxamate (114) was generated. Compound (115) is produced from the Boc-protected precursor, and it reacts with (i)...
Additionally, blaCMY AmpC gene mutations were found to reduce the inhibitory effect of avibactam and thus could be a precursor to developing resistance to the aztreonam-avibactam combination. However, the prior study by Sadek indicates that, absent PBP3 modification, the presence of blaCMY ...