Sequence analysis indicates that the protein is more closely related to freestanding counterparts found in prokaryotes and chloroplasts than it is to the beta-ketoacyl synthase domain of the human cytosolic fatty acid synthase. The full-length nuclear-encoded 459-residue protein includes an N-terminal...
In contrast to the multi-domain mammalian type I fatty acid synthase (FASI) com- plex, each reaction of the FASII pathway is catalysed by a discrete enzyme (see Zhang, et al.13, Cronan and Thomas14, and Parsons and Rock15 for comprehensive reviews). The β -ketoacyl-acyl carrier ...