The Chain Length Factor (CLF)is used to facilitate and examine the differences between the three different groups of Polyketide synthases. The current work has pinpoint the evolution among differentsites in CLF proteins. Maximum-Likelihood analysis elucidatedthat most of these sites were present in ...
Role of conserved residues in the beta-ketoacyl synthase-chain length factor heterodimer. Type II polyketide synthases (PKSs) are a family of multienzyme systems that catalyze the biosynthesis of polyfunctional aromatic natural products such as ... J Dreier,C Khosla - 《Biochemistry》 被引量: ...
(ACP) activity; β-ketoacyl-ACP synthase (KS) activity; acyltransferase (AT) activity; β-ketoacyl-ACP reductase (KR) activity; FabA-like β-hydroxyacyl-ACP dehydrase (DH) activity; non-FabA-like dehydrase activity; chain length factor (CLF) activity; malonyl-CoA:ACP acyltransferase (MAT) ...