Thalassemia minor, the least severe form of the disorder, is characterized by minimal to mild symptoms. Though considered a major cause of morbidity and mortality worldwide, there is still no universally available cure for thalassemia major. The reason for this is, at least in part, due to ...
Dr. Neel recognized that the parents of children with thalassemia major had thalassemia minor with one beta thalassemia gene. When these parents had children, they had a 25% chance of having a thalassemia major child (with both genes for beta thalassemia), a 50% chance of having children with...
Beta thalassemia minor is due to a mutation in one of the beta-globin genes. A person with this condition has less severe symptoms but still can pass along the genes to their children. The possible symptoms of beta thalassemia minor may includeanemia, tiredness, weakness, pale skin, poor ap...
The term thalassemia is derived from the Greek, thalassa (sea) and haima (blood). Beta-thalassemia includes three main forms: Thalassemia Major, variably referred to as "Cooley's Anemia" and "Mediterranean Anemia", Thalassemia Intermedia and Thalassemia Minor also called "beta-thalassemia carrier",...
A novel compound heterozygous of β-thalassemia with HbG-Coushatta: case report of Iran Article Open access 15 May 2023 References Weatherall, D. J., and Clegg, J. B., The Thalassemia Syndromes (Blackwell Scientific Publications, Oxford, 1972). Google Scholar Nienhuis, A. W., and Ander...
Two nonfunctional genes (αα/–) gives rise to a mild anemia (α thalassemia minor syndrome). A single nonfunctional α-globin gene is clinically silent. For the β thalassemias (with two β-globin gene loci), mutations on both of the β-globin gene loci result in homozygous disease;...
Diagnosis of these hematological disorders occurs soon after birth or within the first few years of life due the severe symptoms. The 62 individuals with heterozygous beta thalassemia are asymptomatic and did not receive blood transfusions. They were analyzed to compare the prevalence of T. gon- ...
Therefore, patients who present with symptoms of β-thalassemia minor may not be identified until later in life after undergoing decades of ineffective treatment.β-thalassemia is a multifactorial disease with a variety of clinical presentations that can easily be misdiagnosed as ...
Introduction : There are certain conditions with genetic significance which may affect the life of people even with no any symptoms. One of the most common examples is thalassemia. It is a quantitative hemoglobinopathy with the reduced synthesis of the globin chains of haemoglobin. It is one of ...
Based on the phenotype that it creates, beta-thalassemia and its symptoms can be divided into three forms of minor, intermediate and major. Severe thalassemia (major) caused by inheritance of two mutant alleles of beta-thalassemia. In Intermediate beta-thalassemia, people do not need regular ...