The term thalassemia is derived from the Greek, thalassa (sea) and haima (blood). Beta-thalassemia includes three main forms: Thalassemia Major, variably referred to as "Cooley's Anemia" and "Mediterranean Anemia", Thalassemia Intermedia and Thalassemia Minor also called "beta-thalassemia carrier",...
Two nonfunctional genes (αα/–) gives rise to a mild anemia (α thalassemia minor syndrome). A single nonfunctional α-globin gene is clinically silent. For the β thalassemias (with two β-globin gene loci), mutations on both of the β-globin gene loci result in homozygous disease;...
Sickle Cell Beta Thalassemia is a condition characterized by the inheritance of one β S gene and a thalassemia defect on the other β gene, resulting in variable amounts of protein production and similarities to sickle cell anemia in hematology and prognosis. ...
This article is cited by Evaluation of craniofacial anthropometry of children with β-thalassemia major in the eastern Anatolia: a case–control study Çiğdem Çetin Genç Celal Genç Fatma Demir Yenigürbüz Clinical Oral Investigations (2023)...
Malaria in sickle trait and beta-thalassemia trait.Blood(10), 3364–3371. (1979). ADSCASPubMedGoogle Scholar Hemoglobinopathic erythrocytes affect the intraerythrocytic multiplication of.J. Infect. Dis.(7), 1100–1109. PubMedPubMed CentralGoogle Scholar ...
We have recently seen three examples of thalassemia minor and used the opportunity to acquire information about the immunostatus since the genetic defect of hemoglobin synthesis and/or the increased turnover of erythrocytes and iron overload might be accompanied by alterations of the immune competence...
Beta-thalassemia major patients are at increased risk of complications including endocrinopathies and bone disease due to iron overload. So, this study aimed to assess the growth parameters, serum levels of 25-OH-vitamin D, calcium, and phosphorous in ch
Agarwal S, Arya V, Stolle CA, Pradhan M: A novel Indian beta-thalassemia mutation in the CACCC box of the promoter region. Eur J Haematol. 2006, 77: 530-532. 10.1111/j.0902-4441.2006.t01-1-EJH2923.x. Article CAS PubMed Google Scholar Hardison R, Chao KM, Adamkiewicz M, Price D,...
Hemoglobinopathies and Thalassemias Amer Wahed MD, Amitava Dasgupta PhD, DABCC, in Hematology and Coagulation, 2015 4.2 Hemoglobin Structure and Synthesis Hemoglobin, the oxygen-carrying pigment of erythrocytes, consists of a heme portion (iron-containing chelate) and four globin chains. Six distinct...
Highly stable and facile one-pot copper nanoclusters (Cu NCs) coated with poly(allylamine hydrochloride) (PAH) have been synthesized for selectively sensing deferasirox (DFX) in β-thalassemia plasma. DFX is an important drug used for treating iron overloading in β-thalassemia, but needs to be...