In Patients with Minor Beta-Thalassemia, Cognitive Performance Is Related to Length of Education, But Not to Minor Beta-Thalassemia or Hemoglobin LevelsAhmadpanah, MohammadAsadi, YasamanHaghighi, MohammadGhasemibasir, HamidrezaKhanlarzadeh, Elham...
Related to Beta thalassemia:Alpha Thalassemia thal·as·se·mi·a (thăl′ə-sē′mē-ə) n. An inherited form of anemia occurring chiefly among people of Mediterranean descent, caused by faulty synthesis of part of the hemoglobin molecule. Also calledMediterranean anemia. ...
The thalassemias are a group of inherited hematologic disorders caused by defects in the synthesis of one or more of the hemoglobin chains. Alpha tha..
Beta-thalassemia is caused by the reduced (beta+) or absent (beta0) synthesis of the beta globin chains of the hemoglobin tetramer. Three clinical and hematological conditions of increasing severity are recognized, i.e., the beta-thalassemia carrier state, thalassemia intermedia, and thalassemia ma...
Beta-thalassemia minor Carriers of thalassemia minor are usually clinically asymptomatic but sometimes have a mild anemia. When both parents are carriers there is a 25% risk at each pregnancy of having children with homozygous thalassemia. Dominant beta-thalassemia ...
Thalassemia minor is clinically asymptomatic but some subjects may have moderate anemia. Beta-thalassemias are caused by point mutations or, more rarely, deletions in the beta globin gene on chromosome 11, leading to reduced (beta+) or absent (beta0) synthesis of the beta chains of hemoglobin ...
Thalassemia minor, the Gilbert mutation, and the risk of gallstones. Haematologica 2003;88:1106 –1109. 75. Galanello R, Perseu L, Melis MA, et al. Hyperbilirubinaemia in heterozy- gous beta-thalassaemia is related to co-inherited Gilbert's syndrome. Br J Haematol 1997;99:433– 436. ...
Significantly, RDW is usually normal in thalassemias and anemia of chronic disorders. Thus a low MCV with a high RDW indicates presence of iron deficiency with a sensitivity of over 90%. Low MCV with a normal RDW usually suggests a minor or major thalassemia. High MCV with an elevated RDW...
Hydroxyurea (HU) is one of several agents that have been shown to enhance hemoglobin (Hb) F levels in patients with sickle cell disease and may be useful as a therapy for beta-globinopathies. However, limited information exists on the effects of HU in patients with thalassemia. Accordingly,...
4280 Beta thalassemia intermedia syndromes are serious conditions for which there is no satisfactory therapy to correct the underlying globin chain imbalance. Some agents that induce fetal globin gene expression have ameliorated anemia in thalassemia patients by reducing the imbalance in alpha: non-alpha...