Key Words: alpha-thalassemia, HbH disease, Hb Bart, hydrops fetalis Alpha-thalassemia is one of the most common hemoglobin genetic abnormalities. The primary defect is the reduced or absent production of the alpha globin chains, which constitute the moieties of several hemoglobin (Hb) types, ...
ThalassemiaHemoglobins, AbnormalPrevalenceInfant, NewbornPakistanFemaleMaleThe level of Hb Bart's is directly related to the inheritance of gene. Hb electrophoresis for Hb Bart's in the cord blood is a very simple method of finding out the prevalence of gene in a given population. A study was...
Loss of α-hemoglobin–stabilizing protein impairs erythropoiesis and exacerbates β-thalassemia. J. Clin. Investig. 114, 1457–1466 (2004). Article CAS PubMed PubMed Central Google Scholar Yu, X. et al. An erythroid chaperone that facilitates folding of α-globin subunits for hemoglobin ...
This study examines the effect of different levels of fetal hemoglobin (Hb F) and the presence or absence of genes for -thalassemia on the red cell indices and degree of anemia among 102 patients with homozygous sickle cell disease (S/S) between the ages of 15 and 62 years. Patients were...
The mild homozygous beta zero-thalassemia in this family may result from interactions of a non-deletion alpha-thalassemia, a gene responsible for high proteolytic activity permitting more balanced globin-chain levels, or from an unusually active hemoglobin F production in the proposita. 展开 ...
The presence of associated alpha thalassemia resulted in a reduction in the hemoglobin levels and red cell indices in normal, sickle heterozygous and sickle homozygous newborn babies, MCV and MCH being strong discriminators of alpha thalassemia with two alpha gene deletions in all the three groups....
ThalassemiaFetal HemoglobinPhenotypeAdolescentAdultChildChild, PreschoolTo define the natural history of sickle cell anaemia a cord blood screening programme was initiated and during the first 3 years a total of 129 newborns with FS phenotype were detected, of whom 83 infants were followed up regularly...
alpha-Thalassaemia trait should be considered in all patients of 'high-risk' ethnic origins with a blood picture suggestive of beta-thalassaemia trait but in whom the levels of Hb A2 and Hb F are within normal limits. 展开 关键词: Humans Thalassemia Fetal Hemoglobin Blood Cell Count Infant, ...
Beta thalassemia and Hb Lepore heterozygotes included in this study exhibit fetal hemoglobin levels varying from trace quantities to 14% (1.74 g/dl) of tot... I Gon?Alves,R Ducrocq,J Lavinha,... - 《American Journal of Hematology》 被引量: 54发表: 1998年 The first case of Hb Groene...
Beta-thalassemia with exceptionally high hemoglobin A2. Differential expression of the delta-globin gene in the presence of beta-thalassemia Hemoglobin A2 levels in normal adults are rarely greater than 3.5%. In patients heterozygous for beta-thalassemia, they average about 5% but do not usually......