At birth, a baby with thalassemia major seems entirely normal. This is because the predominant hemoglobin at birth is still fetal hemoglobin (HbF). HbF has two alpha chains (like Hb A) and two gamma chains (unlike Hb A). It has no beta chains so the baby is protected at birth from t...
BETA-ThalassemiaCHILD behaviorPSYCHOLOGICAL testsTEENAGERSMENTAL depressionDELIRIUMBackground: Thalassemia major (TM) is a long-term illness that affects the child and family emotionally and psychologically. Aim: To assess the existence of psychiatric symptoms in thalassemia-affected child...
Beta thalassemia major is also known asCooley’s anemia. In this form of beta thalassemia, both beta globin genes have deletions. It is the most severe form of thalassemia. The signs and symptoms of this condition may include pale or yellowish skin, yellow eyes, extreme fatigue, abdominal pai...
Major beta thalassemia (MBT) is a hereditary disease which synthesies defects in beta chains of haemoglobin, it is causes red blood cell destruction and the symptoms of anemia. Red blood cell destruction, frequent blood transfusion and low adherence to routine use of iron chelator lead to iron ...
- Severe HbE/beta-thalassemia: The Hb level can be as low as 4-5 g/dl. Patients in this group manifest symptoms similar to thalassemia major and are treated as thalassemia major patients. Patients with HbC/beta-thalassemia may live free of symptoms and be diagnosed during routine tests. Whe...
Beta-thalassemia stands as an autosomal recessive disorder that occurs as a result of a defect in the beta-globin chain synthesis of hemoglobin. Oxidative stress has a crucial role in the β-thalassemia pathophysiology. It occurs due to erythroid expansi
In Dutch beta thalassemia homozygotes HbF levels are markedly elevated whereas in heterozygotes, the HbF value ranges from 4 to 11 % [[8], [9]]; overall patients exhibit minimal clinical symptoms, such as mild anemia. This deletion has not been previously reported from Rajasthan, and this ...
there are many unusual sites where EMH can occur. The authors report two cases of intracranial extramedullary hematopoiesis in beta thalassemia. In one of these patients, epidural soft tissue was detected along frontal and parietal convexities causing compression of brain parenchyma leading to raised ...
A lack of red blood cells, also known as anemia, is the primary manifestation of beta thalassemia. Because of this anemia, people living with beta thalassemia may experience fatigue and shortness of breath, and infants may develop failure to thrive, jaundice and feeding problems. Complic...
Background Hemoglobin E/??-thalassemia is particularly common in Southeast Asia and has variable symptoms ranging from mild to severe anemia. Previous inve... S Ponnikorn,T Panichakul,K Sresanga,... - 《Journal of Translational Medicine》 被引量: 18发表: 2011年 Validation of the immunochromat...