Beta-thalassaemia major: Prevalence, risk factors and clinical consequences of hypercalciuriadeferasiroxhypercalciuriarenal diseasethalassemiaORAL IRON CHELATORRENAL TUBULAR FUNCTIONBONE-MINERAL DENSITYGROWTH-F
Beta thalassemia major (BTM) occurs due to the impairment in the production of beta-globin chains causing ineffective erythropoiesis and severe microcytic hypochromic anemia which requires regular blood transfusion [1]. Nearly 23,000 children are born every year with BTM [2]. Majority of these chil...
Dr. Neel recognized that the parents of children with thalassemia major had thalassemia minor with one beta thalassemia gene. When these parents had children, they had a 25% chance of having a thalassemia major child (with both genes for beta thalassemia), a 50% chance of having children with...
Thalassemia intermedia and major View chapter Book 2017,Nitric Oxide (Third Edition) Chapter Pulmonary Manifestations of Systemic Disorders GENETICS Thesickle cellsyndromes comprise three types of anemia—sickle cell disease (hemoglobin SS), sickle cell β-thalassemia (hemoglobin S-thal), andsickle cell...
TDT imposes substantial disease burden with lifelong Red blood cell (RBC) transfusions [4] and iron-chelation therapy and significantly restricts their life expectancy and quality of life [5]. Hematopoietic stem cell transplantation is the only cure for β-thalassemia major which often lacks ...
Osteopenia and/or Osteoporosis (OOS) is becoming an increasingly prevalent chronic disease among Beta Thalassemia Major (BTM) patients, especially now that life expectancy in these patients has considerably improved through regular blood transfusions and iron chelation therapy. With several, complex ...
However, these patients face with newer challenges which influence their quality of life (QoL). In this study, the aim of this study was to measure QoL among patients with β-thalassemia major (β-TM).Methods&58; A cross-sectional study was done at the thalassemia centre of Shahrekord ...
However, these\\udpatients face with newer challenges which influence their quality of life (QoL). In this\\udstudy, the aim of this study was to measure QoL among patients with β-thalassemia\\udmajor (β-TM).\\udMethods: A cross-sectional study was done at the thalassemia centre of ...
Background β–thalassemia major (β–TM) is a hereditary genetic disease hindered by many comorbidities due to transfusion–related iron. Despite iron chelation therapy increased the life expectancy up to 50 years today, Iron–related heart disease is still a leading complication, with an expected...
Beta-thalassemiaDXAplatyspondylyTBSvertebral deformitiesVertebral fractures in beta-thalassemia major are increasingly found because of the longer life expectancy of patients, with a major negative impact on their quality of life. We performed a retrospective cross-sectional study to investigate the ...