Conversion of a beta- strand to an alpha-helix induced by a single-site mutation observed in the crystal structure of Fis mutant Pro26Ala. Protein Sci. 7: 1875-83.Yang W-Z, Ko T-P, Corselli L, Johnson RC, Yuan HS (1998) Conversion of a β-strand to an α-helix induced by a ...
Conformational changes, from beta-strand to alpha-helix, of the fatty acid-binding protein ReP1-NCXSQ in anionic lipid membranes: dependence with the vesicle curvatureReP1-NCXSQLipid membraneProtein conformational changeInfrared spectroscopyCircular dichroismMembrane curvature...
Barik,S. (2004) When proteome meets genome: the alpha helix and the beta strand of proteins are eschewed by mRNA splice junctions and may define the minimal indivisible modules of protein architecture. J. Biosci., 29, 261-273.Barik, S. (2004) When proteome meets genome: the alpha helix...
Top views are shown, β-strands at the interface are indicated as colored dots (same color scheme as in a); the red dot indicates the β4-strand where E73 is located (arrowheads); the N-terminal helix is shown as a gray oblong within the VDAC1 pore. h Snapshot side-view of VDAC ...
The Alzheimer β-peptide shows temperature-dependent transitions between left-handed 3-helix, β-strand and random coil secondary structures. FEBS J. 272, 3938–3949. https://doi.org/10.1111/j.1742- 4658.2005.04812.x (2005). 51. Jarvet, J., Danielsson, J...
It is noteworthy that oxidation of DNA can result, in addition to base oxidation, in DNA strand breaks, which could contribute to neurodegeneration by favoring the formation of neurofibrillary tangles [90]. Cholesterol in cell membranes, more specifically in microdomains rich in cholesterol named ...
The 3D structure of residues 15-42 of Aβ42 adopts a double-horseshoe-like cross-β-sheet entity with maximally buried hydrophobic side chains, in which residues 1-14 are partially ordered and in a β-strand conformation, which is the more neurotoxic species, aggregates much faster, and ...
Soto et al., The alpha-helical to beta-strand transition in the amino-terminal fragment of the amyloid beta-peptide modulates amyloid formation,J. Biol. Chem.270:3063-3067 (1995) Soto et al., Apolipoprotein E increases the fibrillogenic potential of synthetic peptides derived from Alzheimer's...
In this embodiment, each strand comprises nucleotide sequence that is complementary to nucleotide sequence in the other strand; such as where the antisense strand and sense strand form a duplex or double stranded structure, for example wherein the double stranded region is about 15 to about 30, ...
Single-stranded DNA or RNA may be the coding strand, also known as the sense strand, or it may be the non-coding strand, also referred to as the anti-sense strand.By “isolated” nucleic acid molecule(s) is intended a nucleic acid molecule, DNA or RNA, which has been removed from ...