This section provides a quick introduction of protein secondary structures, alpha helix and beta sheet. Both structures are stabilized by hydrogen bonds between oxygen atoms and hydrogen atoms of two amino acid residues lined up side by side.©...
Alpha Helix and Beta Sheet The primary structure of a protein is the amino acid sequence of the polypeptide chain. The way the polypeptide chain forms hydrogen bonds determines the secondary structure. There are two main types of secondary structures in proteins, alpha helices and beta pleated ...
We describe a general strategy for creating peptidic oligomers that have unnatural backbones but nevertheless adopt a conformation very similar to the alpha-helix. These oligomers contain both alpha- and beta-amino acid residues (alpha/beta-peptides). If the beta content reaches 25-30% of the ...
- The alpha-helix is stabilized by intramolecular hydrogen bonds. - It typically contains light R-groups such as glycine, alanine, and valine, which allow for the tight coiling of the helix. 4. Formation of Beta-Pleated Sheet: - The beta-pleated sheet is formed when two or more linear po...
Alpha-helix and beta-barrel pore-forming toxins (leucocidins, alpha-, gamma-, and delta-cytolysins) of Staphylococcus aureus. In The Comprehensive Sourcebook of Bacterial Protein Toxins; Elsevier: Amsterdam, The Netherlands, 2006; pp. 590-607....
beta-sheet to alpha-helix conversionThe effect on protein conformation and thermal stability was studied for beta-Galactosidase (beta-Gal) encapsulated in the nanopores of a silicate matrix (E beta-Gal). Circular dichroism spectra showed that, compared with the enzyme in buffer (S beta-Gal), E...
Leng, “Application of FTTP to Alpha-Helix or Beta-Strand Motifs,” Journal of Theoretical Biology, Vol. 242, No. 1, 2006, pp. 199-219. doi:10.1016/j.jtbi.2006.02.014Yang J,Dong X C,Leng Y.Application of FTTP to alpha-helix or beta-strand motifs. Journal of Theoretical Biology . ...
Nesmelova, I., Krushelnitsky, A., Idiyatullin, D., Blanco, F., Ramirez-Alvarado, M., Daragan, V. A., Serrano, L. & Mayo, K. H. Conformational exchange on the microsecond time scale in alpha-helix and beta-hairpin peptides measured by 13C NMR transverse relaxation. Biochemistry ...
Here we present the crystal structure of an alpha/beta-peptide foldamer that adopts a tetrameric helix-bundle quaternary structure with a hydrophobic core composed solely of beta-amino acids. The structure displays features that are unprecedented among all known helix bundles composed of either alpha...
Synthesis of new 1,2-dideoxy C-linked carbo-beta-amino acids and alpha/beta-peptides with 11/9-helix, helix-turn and helix-turn-helix structuresHelix-turn-helixHelix-turnbeta(3)-amino acidsTetrahedron furan side chainMosher amidesThe present study describes the synthesis of new C-linked carbo...