β-Oxidation of very long chain fatty acids and their coenzyme A derivatives by human skin fibroblasts. Arch. Biochem. Biophys. 254 (1987a) 526–533Singh, H., Derwas, N., and Poulos, A. (1987). β-Oxidation of
2.4Beta-oxidation Beta-oxidation describes the enzymatic removal of carbon molecules from a fatty acid chain, beginning at the beta-carbon. This is catalyzed by a family of acyl-CoA dehydrogenases, which include short-, medium-, long-, and very long- chain acyl-CoAdehydrogenase[9,21]. There...
The meaning of BETA-OXIDATION is stepwise catabolism of fatty acids in which 2-carbon fragments are successively removed from the carboxyl end of the chain.
Metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation in platinum-resistant cancer cells Yuying Tan, Junjie Li, Guangyuan Zhao, Kai-Chih Huang, Horacio Cardenas, Yinu Wang, Daniela Matei & Ji-Xin Cheng Nature Communications volume 13, Article number: 4554 (...
We concluded that some aspects of oxidative metabolism (possibly the oxidation of tricarboxylic acid-cycle intermediates) are inhibited by very-long-chain fatty acids in some species (e.g. the rat and the cat but not in others (e.g. the pig and the rabbit). 3. It is proposed that the...
oxidation 1.A substance is oxidized if it gains oxygen, loses hydrogen, or loses electrons. 2.A chemical reaction involving loss of electrons. In the human body, oxidation occurs when breathed-in oxygen combines with molecules in food to produce energy, water, and carbon dioxide. ...
(CL-316,243) restores the expression of down-regulated fatty acid oxidation genes in type 2 diabetic mice Amit Kumar1,2, Joseph Shiloach1, Michael J Betenbaugh2 and Emily J Gallagher3* Abstract Background: The hallmark of Type 2 diabetes (T2D) is hyperglycemia, although there are multiple ...
eminence recently due to an increased understanding of their antioxidant effects. Cardioprotective effects of tocotrienols include antagonizing the oxidation of low density lipoproteins, anti-atherosclerotic properties, inhibiting platelet aggregation and monocytes adhesion, and preventing smooth muscle proliferation...
Elevated levels of free fatty acids in plasma might contribute to the loss of beta cells. The objective of this study was to find a chemical that could protect against palmitate-induced beta cell death and investigate whether such chemical could improve hyperglycemia in mouse model of type 2 ...
1A) and the long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) activity (step 2 Fig. 1A), while the beta-subunit carries the long-chain 3-ketoacyl-CoA thiolase (LCKT) activity (step 3 Fig. 1A) and is responsible of the final step of the beta oxidation. [5] The alpha-subunit is ...