Brook I. Emergence and persistence of beta-lactamase producing bacteria in the oropharynx following penicillin treatment. Arch Otolaryngol Head Neck Surg 1988; 114 :667-70.Brook I. Emergence and persistence of beta-lactamase-producing bacteria in the oropharynx following penicillin treatment. Archives ...
Beta-lactamase inhibitorsThe beta-lactamase inhibitors encompass several drugs important for the treatment of nosocomial infections. Sulbactam, clavulanic acid, and tazobactam are the most common members of this class employed for the treatment ofAcinetobacterinfection. Beta-lactamase inhibitors have very lit...
(except the newer fourth-generation agents), allpenicillins,aztreonam, and beta-lactamase inhibitors such astazobactam,clavulanate, andsulbactam.7When this enzyme is present, organisms exhibit clinically significant elevations in their MIC values, which has led to treatment failures.1,8–14One ...
treatment for a concomitant infection; presence of complicated pyelonephritis identi- fied within first 7 days of therapy (emphysematous pyelonephritis, renal parenchymal abscess, perinephric abscess, renal papillary necrosis); prostatitis; extended spectrum beta-lactamase producing, AmpC, or carbapenem-resis...
treatment for a concomitant infection; presence of complicated pyelonephritis identi- fied within first 7 days of therapy (emphysematous pyelonephritis, renal parenchymal abscess, perinephric abscess, renal papillary necrosis); prostatitis; extended spectrum beta-lactamase producing, AmpC, or carbapenem-resis...
Objectives: To describe the impact of extended-spectrum beta-lactamase (ESBL)-positive, multiresistant Klebsiella pneumoniae (MRKP) in the intensive care unit (ICU), and typing of strains. Methods and results: In 21 ICU patients an ESBL-positive MRKP was isolated during a period of 4 months...
(d)monobactams(e.g.aztreonam)(e)beta-lactamaseinhibitors(e.g.clavulanicacid,sulbactam).A.FLEMING(1881–1955)•PenicillinG-P.notatum I.PENICILLINS (1929)Thecellwallcompletelysurroundsthecytoplasmicmembrane,maintainscellshapeandintegrity,andpreventscelllysisfromhighosmoticpressure.Thecellwalliscomposedofa...
beta-lactamase Enzyme (penicillin amido-beta-lactam hydrolase, EC 3.5.2.6, 377aa in E. coli) produced by some bacteria that makes them resistant to beta-lactam antibiotics. Competitively inhibited by clavulanic acid. Extended-spectrum beta lactamases (ESBLs) will degrade the ‘extended spectrum cep...
2020). In recent years, the attention on the epidemiology of multidrug-resistant (MDR) bacteria in both human and veterinary medicine has increased, with the focus on the emergence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae (Poirel et al. 2018). Special attention is ...
A method for determining whether a test bacterium is a class C beta-lactamase-producing bacterium. Spots of a class C beta-lactamase inhibitor and a beta-lactam drug are applied at