The present invention relates to, in part, methods and compositions for reducing the incidence and/or severity of complications associated with IV beta-lactam antibiotic use in allo-HCT recipients, such as aGVHD and VRE colonization and/or VRE bloodstream infection, using beta-lactamase agents....
plasma beta-lactam concentration was associated with reduced probability of positive clinical outcome (defined as the “completion of treatment course without change or addition of antibiotic therapy, and with no additional antibiotics commenced with 48 h of cessation”) [12]. In addition to this sig...
Extended-spectrum 尾-lactamase (ESBL) producing gram-negative bacilli are a growing concern in human medicine today. When producing these enzymes, organism... E Stürenburg,D Mack - 《Journal of Infection》 被引量: 497发表: 2003年 β-Lactam/β-lactam inhibitor combinations for the treatment of...
beta-lactamase resistance beta-lactamase resistant penicillin beta-lactamase resistant penicillin beta-lactamase resistant penicillin Beta-Lactamase-Positive Amoxicillin/Clavulanate-Resistant Beta-Lactamase-Producing Bacteria beta-lactamase-resistant antibiotic ...
Beta-lactamase inhibitors The beta-lactamase inhibitors encompass several drugs important for the treatment of nosocomial infections. Sulbactam, clavulanic acid, and tazobactam are the most common members of this class employed for the treatment of Acinetobacter infection. Beta-lactamase inhibitors have very...
AcidresistantpenicillinsAcidstable(oraladministration),beta-lactamasenon-stablepenicillinsPenicillinV(phenoxymethylpenicillin)Isindicatedonlyinminorinfectionsbecauseofitsrelativelypoorbioavailability,theneedfordosingfourtimesaday,anditsnarrowantibacterialspectrum.Amoxicillinisoftenusedinstead. Penicillinaseresistantpenicillins...
Mechanisms of antibiotic resistance: QM/MM modeling of the acylation reaction of a class A beta-lactamase with benzylpenicillin. Understanding the mechanisms by which beta-lactamases destroy beta-lactam antibiotics is potentially vital in developing effective therapies to overcome ba... Johannes,C,Hermann...
and does not retain any activity against gram-positive organisms or anaerobes (Beauduy & Winston, 2020a;Macdougall, 2020a). The primary role of aztreonam is in the prevention and treatment of gram-negative infections in patients with severe beta-lactam allergies. In terms of safety, aztreonam...
(d)monobactams(e.g.aztreonam)(e)beta-lactamaseinhibitors(e.g.clavulanicacid,sulbactam).A.FLEMING(1881–1955)•PenicillinG-P.notatum I.PENICILLINS (1929)Thecellwallcompletelysurroundsthecytoplasmicmembrane,maintainscellshapeandintegrity,andpreventscelllysisfromhighosmoticpressure.Thecellwalliscomposedofa...
BROOK, I. Emergence and persistence of beta- lactamase-producing bacteria in the oropharynx following penicillin treatment. Arch Otolaryngol Head Neck Sur 114:667-70,1988.Brook I. Emergence and persistence of beta-lactamase- producing bacteria in the oropharynx following peni- cillin treatment. Arch ...