Synthesis of beta-lactamA method of synthesizing monomeric formadelhyde imines in situ by reacting (cyanomethyl)- or (aminomethyl)-amines with organometal or Grignard reagents, and their use to synthesize 2-azetidinones (β-lactams) via reaction with enolates.Overman Larry E....
E.5.thedurationofprocainepenicillinislong:A.alteredthechemicalstructureofpenicillinDecreasedB.excretionC.uptakedecreasedD.damagereductionE.increasedenterohepaticcirculationThetargetof6.betalactamantibioticsis:A.bacterialoutermembraneB.peptidelayerC.cytoplasmD.PBPsE.mucuslayer7.themainantibacterialmechanismofpenicillins...
The synthesis of beta-lactam structures is now feasible by solid-phase methods.Reports on the study conducted by M. Chmielewski and co-authors on the feasibility of the synthesis of beta-lactam structures by solid-phase methods. Steps in the reaction sequence; Resin used in the solid-phase ...
Design and synthesis of monocyclic beta-lactams as mechanism-based inhibitors of human cytomegalovirus protease. Mechanism based inhibitors of HCMV protease have been designed based on the monocyclic beta-lactam nucleus, which have been shown to acylate the viral enzy... Borthwick,AD,Weingarten,......
Thebetalactamringisanecessarygroupofbetalactamantibiotics.Duringtheactionwithbacteria,thebetalactamringopensandthebacteriaundergoacylationtoinhibitbacterialgrowth.Themechanismofactionofpenicillinistoinhibitthesynthesisofbacterialcellwalls.Thebetalactamringisafourmemberedringwithlargetensionandunstablechemicalpropertiessothat...
BETA-LACTAMANTIBIOTICS(inhibitorsofcellwallsynthesis)Theirstructurecontainsabeta-lactamring.Themajorsubdivisionsare:(a)penicillinswhoseofficialnamesusuallyincludeorendin“cillin”(b)cephalosporinswhicharerecognizedbytheinclusionof“cef”or“ceph”intheirofficialnames.(c)carbapenems(e.g.meropenem,imipenem)(d)mono...
One of the most commonly utilized groups of antimicrobial agents is the beta-lactam class of antibiotics. Although this class is comprised of a wide variety of agents, all beta-lactams share a similar structure, including a beta-lactam ring, which contributes to their mechanism of action (Beau...
a) The need to maximize the desired synthesis reaction catalyzed by the enzyme and to minimize the undesired side reactions catalyzed by the same enzyme, such as hydrolysis of the activated side-chain components and of the beta-lactam antibiotic (see the reaction mechanism below). Reaction mecha...
Enzymatic synthesis of beta-lactam antibiotics. Analytical review Production of by acyl transfer enzymatic synthesis with immobilised synthetase from as a biocatalyst acting in accordance with the mechanism including form... VB Kurochkina,AV Skliarenko - Antibiotiki i khimioterapii͡a = Antibiotics ...
Efficient and highly stereoselective synthesis of a β-Lactam inhibitor of the serine protease prostate-specific antigen Graphic R Annunziata,M Benaglia,M Cinquini,... - 《Bioorganic & Medicinal Chemistry》 被引量: 84发表: 2002年 A highly stereoselective and practical total synthesis of the ...