The extensive production and usage of antibiotics have led to an increasing occurrence of antibiotic residuals in various aquatic compartments, presenting a significant threat to both ecosystem and human health. This study investigated the degradation of selected β-lactam antibiotics (penicillins: ampicill...
Theoretical study of the hydrolysis mechanism of β-lactam antibiotics catalysed by a Zn(II) dinuclear biomimetic organometallic complex Juan E. ZuritaJosé R. MoraFelix Martinez-RiosStephen J. BarigyePatricio J. Espinoza-Montero
Mechanism of action of beta-lactam antibiotics at the mo- lecular level. Biochem Pharmacol 26:2203-2210. http://dx.doi.org/ 10.1016/0006-2952(77)90280-5.Frere, J.M. Mechanism of action of beta-lactam antibiotics at the molecular level. Biochem. Pharmacol. 1977, 26, 2203-2210. [Cross...
On the other hand, indirect degradation also occurs through the generation of reactive radicals due to the absorption of UV Conclusions This study evaluated both kinetics and mechanisms of the degradation of four model β-lactam antibiotics. It was found that direct UV irradiation led to various ...
ChemInform Abstract: Penicillin‐Bound Proteins. The Target of β‐Lactam Antibiotics. Mechanism of Action of β‐Lactamases and Their Inhibitorsbiochemistry, reviewantibioticspharmacology, medicinal chemistry, vaccines, serumsChemInform is a weekly Abstracting Service, delivering concise information at a ...
Cilastatin is an inhibitor of renal dehydropeptidase, an enzyme responsible for both the metabolism of thienamycin beta-lactam antibiotics as well as conversion of leukotriene D4 to leukotriene E4. Since the antibiotic, imipenem, is one such antibiotic that is hydrolyzed by dehydropeptidase, cilastat...
PR Andrews,DJ Craik,JL Martin - 《Journal of Medicinal Chemistry》 被引量: 996发表: 1985年 Penicillin-binding proteins and the mechanism of action of beta-lactam antibiotics. This article analysis the role of academic library collections and services, which have contributed to the development of ...
Ampicillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Amp...
Mechanism of Action Cefepime belongs to the β-lactam group of antibiotics and its mechanism of action is similar to that of other β-lactam antibiotics. Cefepime inhibits bacterial cell wall synthesis by covalently binding to the enzyme responsible for the final step of transpeptidation in peptidog...
The FtsZ protein is a central component of the bacterial cell division machinery. It polymerizes at mid-cell and recruits more than 30 proteins to assemble into a macromolecular complex to direct cell wall constriction. FtsZ polymers exhibit treadmilling