A final metabolic consideration with losartan is its degree of interaction with grapefruit juice. Although not formally tested as to its influencing the BP-lowering effect of losartan, grapefruit juice given together with losartan will reduce its conversion to E-3174 as well as activate P-...
Grapefruit juice Coadministration of 240 mL ofgrapefruitjuice with a single oral dose of amlodipine 10 mg in 20 healthy volunteers had no significant effect on the pharmacokinetics of amlodipine. Maalox®(antacid) Coadministration of the antacid Maalox with a single dose of amlodipine had no sig...
levels has been found, nor is there any interaction withcimetidine(in contrast to verapamil and nifedipine). Because of the hepaticCYP3A4interaction, the FDA warns that the 20-mg dose ofsimvastatinshould not be exceeded in patients taking amlodipine. There is no known effect of grapefruit juice...