Trk有A、B、C三种,TrkA(基因名NTRK1)是NGF的特异性受体,TrkB(NTRK2)是BDNF和NT-4的特异性受体,TrkC(NTRK3)是NT-3的特异性受体。 TrkA、TrkB、TrkC均由约800个氨基酸组成,经过糖基化成为分子量140-145 kDa的功能性分子。它是一种在细胞内具有激酶结构域的受体酪氨酸激酶。当二聚体配体结合时,Trk自身也会...
Neither brain-derived neurotrophic factor (BDNF; Wald chisq = 0.00, df =1, p =0.95) nor tyrosine kinase B (NTRK2; Wald chisq = 0.41, df =1, p =0.52) transcript expression were altered in the ACC of subjects with completed suicide compared to other causes of death. In the DLPFC of ...
产品活性:BDNF 蛋白是一种重要的信号分子,可激活 NTRK2 下游级联并影响神经元发育和功能的多种作用。它促进周围和中枢神经系统的存活和分化,影响轴突和树突的生长。BDNF 蛋白, Mouse (R129A, R130A, HEK293, C-His) 是重组的 BDNF 蛋白,由 HEK293 表达,带有 C-6*His 标签。 和 R129A,R130A,, 突变。BD...
PGC由多种组织学亚型组成,几种关键蛋白的表达水平是预测PGC预后和治疗策略的重要特征。然而,PGC的分子特征知之甚少。 原肌球蛋白受体激酶(TRK)家族由三种酪氨酸激酶受体组成:TRKA、TRKB和TRKC,分别由NTRK1,NTRK2和NTRK3基因编码。在各种人类恶性肿瘤中观察到异常的TRK信号传导,TRK家族正在成为抗癌治疗的关键靶标。原...
BDNF在哺乳动物大脑中表达丰富,其主要受体为TrkB/ Ntrk2,主要表达于神经元、皮层和DG以及 很少有星形胶质细胞和小胶质细胞通过单细胞测序确定。BDNF也有 对p75受体的结合亲和力,主要在哺乳动物的神经元中表达 。然而,在斑马鱼中,ngfra主要在NSCs中表达,并负责 为NSC塑性。斑马鱼神经胶质细胞通过ngfra受体对BDNF产生应答...
responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. Binds to NTRK2/TRKB. It is converted into mature BDNF by plasmin (PLG). Belongs to the NGF-beta ...
(LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. POst translation modification: Converted into mature BDNF by plasmin (PLG). ...
简称兔抗-BDNF/NT-3生长因子受体多克隆抗体(NTRK2)[技术抗人,多克隆,抗体,兔,抗 替代名称生产品种:兔抗-H.智人脑源性神经营养因子/NT-3生长因子受体多克隆(抗体)(NTRK2)[替代技术多克隆 联系我们询问抗人、多克隆、抗体、兔、抗BDNF/NT-3生长因子受体(NTRK2)选择审核1。基因信息 ...
The Interaction of BDNF and NTRK2 Gene Increases the Susceptibility of Paranoid Schizophrenia. The association between BDNF gene functional Val66Met polymorphism rs6265 and the schizophrenia is far from being consistent. In addition to the heterogene... Lin,Zheng,Yousong,... - 《Plos One》 被引...
BDNF有两类受体,一类为高亲和力的受体Trk(原肌球蛋白受体激酶)家族,Trk家族包括TrkA、TrkB和TrkC三种蛋白,分别由NTRK1、NTRK2和NTRK3基因编码,TrkA与神经营养因子(NGF)结合,TrkB与BDNF和神经营养因子4(NT-4)结合,TrkC与神经营养因子3...