a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing ...
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact wi...
BCL10 gene mutations rarely occur in lymphoid malignancies. Leukemia 2000; 14:905-8.S. Luminari, D. Intini, L. Baldini, E. Berti, F. Bertoni, E. Zucca, L. Cro, A.T. Maiolo, F. Cavalli, A. Neri, bcl-10 gene mutations rarely occur in lymphoid malignancies, Leukemia 14 (2000) ...
and activation of NF-kappa-B via NIK and IKK. BCL-10 is also an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. It is a substrate for MALT1. Mutations in the gene can lead to Immmunodeficiency 37 or Lymphoma, mucosa-associ...
BCL10 is not the gene inactivated by mutation in the 1p22 deletion region in mantle cell lymphoma. Leukemia, 14: 1490-1492.Bullinger, L., Leupolt, E., Schaffner, C., Mertens, D., Bentz, M., Lichter, P., Do¨hner, H. & Stilgenbauer, S. (2000) BCL10 is not the gene ...
The gene encoding BCL10 was identified by its recurrent translocation t(1;14)(p22;q32) in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. BCL10 contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. Properties Storage Ins...
Gene Name: BCL10 Protein Name: B-cell lymphoma/leukemia 10 Human Gene Id: 8915 Swiss-Prot: O95999 Formulation: PurIF:ied antibody in PBS containing 0.03% sodium azide. Source: Monoclonal, Mouse Dilution: WB: 1:500-1:2000 IHC: 1:200-1:1000 IF: 1:200-1:1000 FCM: 1:200-1:400 ELI...
Human Gene Id: 53358 Swiss-Prot: Q92529 Formulation: Liquid in PBS containing 50% glycerol, and 0.198% sodium azide. Source: Polyclonal, Rabbit Dilution: WB: 1:500-2000 Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. Concentrat...
Bioinformatics analysis was performed to predict the characteristics of BCL-10, the results indicated that IBCL-10/I gene encoded a polypeptide, molecular mass of 45 Ku and comprising 233 amino acids. The prediction of secondary structure showed that BCL-10 had 9 alpha-helix, 1 beta-sheet, 12...
BCL10 genemutationPCR‐SSCPchildhood cancerBACKGROUND: , a gene involved in signaling, has recently been identified at 1p22. This gene was found to be mutated in several types of and other kinds of . Especially in , high mutation rates have been reported. These findings suggest that its ...