BCG Vaccine Description BCG VACCINE for percutaneous use is an attenuated, live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of Mycobacterium bovis.{1} The TICE® strain used in this BCG VACCINE preparation was developed at the University of Illinois from a strain ...
Mycobacterium bovis BCG is the human tuberculosis vaccine and is the oldest vaccine still in use today with over 4 billion people vaccinated since 1921. The BCG vaccine has also been investigated experimentally in cattle and wildlife by various routes including oral and parenteral. Thus far, oral ...
In this field study, the efficacy of long-term vaccination with BCG of adult and replacement goat kids was evaluated. The vaccine efficacy was determined as the reduction of prevalence, the AF, and the reduction of incidence of each herd during three years, by using IGRA responses against DIVA...
aAn IGRA may be preferable to a TST for students who have had a BCG vaccine since there is minimal chance for a false positive from an irga IGRA也许是更好的对TST为有BCG疫苗的学生,因为有最小的机会为假阳性从irga[translate]
Our aim was to develop a new BCG vaccine that is compatible with a sensitive and affordable DIVA skin test. The approach we used is based on the observation that at least three M. bovis antigens (ESAT-6, CFP-10 and Rv3615c) are dispensable for the protective efficacy of BCG. This led...
DAR-901 was safe and well-tolerated. One DAR-901 recipient developed a vaccine site abscess. Neither the primary nor secondary endpoints differed between the two treatment arms (p = 0.90 and p = 0.20, respectively). DAR-901 IGRA converters had median responses to ESAT-6 of 50.1 spot-...
Tuberculosis (TB) remains the deadliest infectious disease1, and the widely used Bacillus Calmette–Guérin (BCG) vaccine fails to curb the epidemic. An improved vaccination strategy could provide a cost-effective intervention to break the transmission cycle and prevent antimicrobial resistance2,3. Limi...
12 and 18 months post-vaccination, and infection status was determined using a diagnostic procedure which discriminates the infected amongst vaccinated animals. On average, the BCG vaccine showed a low but significant level of protection (22.4%) at the end of the trial, although diverse levels of...