This highly homologous protein to the AtBI-1 protein was named CsBI-1. This protein contains an open reading frame (ORF) of 250 amino acids with a BAX inhibitor domain and five transmembrane regions conserved among members of the BI-1 family. Primers designed by the cDNA of CsBI-1 gene ...
The overexpression of Bax inhibitor-1 (BI-1) in prostate carcinoma and prostate cancer cell lines was confirmed by using Northern blot and Western blot analyses. Quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) on intact RNAs from 17 paired laser-captured micro...
Bax Inhibitor-1 (BI-1) is an evolutionary conserved endoplasmic reticulum (ER)-located protein that protects against ER stress-induced apoptosis.1This function has been closely related to its ability to permeate Ca2+from the ER2and to lower the steady-state [Ca2+]ER.3BI-1 may function as ...
1. Introduction BAX inhibitor-1 (BI-1) is an anti-apoptotic protein of seven transmembrane domains first identified in a screen for human proteins capable of inhibiting BAX-mediated cell death in yeast [1]. In mammals, its cytoprotective properties are most evident in paradigms of endoplasmic re...
41. Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005; 435: 677–681. 42. Walensky LD, Gavathiotis E. BAX unleashed: the biochemical transformation of an inactive ...
Many proteins bearing this motif have been identified and incorporated into the public databases including three novel antiapoptotic proteins, Bax Inhibitor-1 (BI-1), Lifeguard (LFG), and h-GAAP. It has been proposed that BI-1 and LFG and probably other closely related proteins represent a new...
To further investigate the mechanisms involved in the anti-apoptotic effect of electrical activity, we blocked BAX by application of the BAX inhibitor peptide V5 (10 µM 13 175 Page 14 of 20 J. Schroer et al. Fig. 6 Activity-dependent downregulation of the BAX/BCL-2 ...
Bax inhibitor-1 Mouse embryonic stem cell Mitogen-activated protein kinase Neuronal differentiation 1. Introduction Embryonic stem (ES) cells are pluripotent cells derived from the inner cell mass of blastocysts and are characterized by their ability to proliferate extensively and differentiate into various...
inhibitor Q-VD-OPH did not affect the cisplatin-induced redistribution of nesprin-1 or nesprin-2 (Fig.1a, b). For confirmation, we usedcaspase-9−/−MEFs, which lack apoptosome-mediated caspase activation. The lack of capsase-9 did not prevent cisplatin-induced nesprin-1 and nesprin...
The present invention provides substantially purified nucleic acid molecules encoding Bax inhibitor protein-1 (BI-1; SEQ ID NO: 1) or Bax inhibitor protein-2 (BI-2; SEQ ID NO: 4), nucleic acid molecules complementary thereto (SEQ ID NO: 2 and SEQ ID NO: 5, respectively), portions of ...