The potent cell death suppression makes this protein family an interesting target for the development of new drugs and gene therapeutic approaches for diseases caused by apoptotic dysregulation, such as cancer. Keywords: Protein family, Bax-inhibitor, programmed cell death, apoptosis inhibitors, ...
2015. The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA(2)(+)-filling state. Biochim Biophys Acta. 1853, 2104-2114.Lisak DA, Schacht T, Enders V, Habicht J, Kiviluoto S, Schneider J, Henke N, ...
The ancient cell death suppressor BAX inhibitor-1. Cell Calcium. 2011 Sep;50(3):251-60 Bax inhibitor-1 (BI-1) was initially identified for its ability to inhibit BAX-induced apoptosis in yeast cells and is the founding member of a family of highly hydrophobic proteins localized in diverse ...
BAX inhibitor-1(BI-1) is a eukaryotic conserved sensor localized in the endoplasmic reticulum (ER). BI-1 is a protein that was initially discovered by screening a complementary DNA library of humans in yeast [8]. BI-1 is commonly referred to as a “cell death suppressor” as its role i...
By exploiting this phenotype, we have identified a novel human Bax inhibitor, BI-1. BI-1 is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments and is predominantly localized to intracellular membranes, similar to Bcl-2 family proteins. Moreover, BI-1...
In the case of insufficient adaptation to ER stress, cells undergo apoptosis.3 BAX (BCL2-associated X protein) inhibitor-1 (BI-1) is an evolutionarily conserved protein that bridges both the Ca2+ homeostasis and UPR functions of the ER.4 BI-1 was first identified in a screen for human ...
MICS1 1. Introduction BAX inhibitor-1 (BI-1) is an anti-apoptotic protein of seven transmembrane domains first identified in a screen for human proteins capable of inhibiting BAX-mediated cell death in yeast [1]. In mammals, its cytoprotective properties are most evident in paradigms of endopla...
Background Bax inhibitor-1 (BI-1) is an evolutionary conserved endoplasmic reticulum protein that, when overexpressed in mammalian cells, suppresses the apoptosis induced by Bax, a pro-apoptotic member of the Bcl-2 family. The aims of this study were: (1) to clarify the role of intrinsic an...
Bax Inhibitor-1 (BI-1) is an evolutionary conserved endoplasmic reticulum (ER)-located protein that protects against ER stress-induced apoptosis.1This function has been closely related to its ability to permeate Ca2+from the ER2and to lower the steady-state [Ca2+]ER.3BI-1 may function as ...
For example, Bax inhibitor 1 protein was involved in innate immunity of Procambarus clarkii. RNA interference result showed that WSSV replication was evidently suppressed and the apoptosis was enhanced under Pc-BI-1 knock down [7]. Another anti-apoptotic protein was inhibitors of apoptosis (IAPs) ...