Treadmill training of spinalized rats creates conditions for early appearance of rhythmic locomotor movements of the hind limbs. Recovery of the movements was paralleled by an appropriate structural organization of neurons in the anterior horns of the distal compartment of the spinal cord....
). Furthermore, we found no correlation between the activity of rACC→Pn neurons and mouse locomotor speed (Extended Data Fig. 3t–v), indicating that these cells are not merely responding to generic movement. To further confirm that increased activity in rACC→Pn neurons corresponds with pain...
Cannabinoid CB2receptor (CB2R) agonists are investigated as therapeutic agents in the clinic. However, their molecular mode-of-action is not fully understood. Here, we report the discovery of LEI-102, a CB2R agonist, used in conjunction with three other CBR ligands (APD371, HU308, and CP...
Understanding how evolutionary pressures have optimized animals' locomotor ability to successfully move in different environments will provide a deeper understanding of how to mimic these movements through mathematical models and robotics.Ross, Ryan B...
Despite the obvious pivotal role played by the trunk during locomotion, most studies devoted to understanding the neural basis of locomotor control have only addressed the operation of the neural circuits driving leg movements, and relatively little is known of the networks that control trunk muscles...
Boylls, C. C. A theory of cerebellar function with applications to locomotion: 11. The relation of anterior lobe climbing fiber function to locomotors behavior in the ca!.COINS Technical Report76-1, Department of Computer and Information Science, University of Massachusetts, 1975. ...
which affect motor control functions, working memory, reward and goal-directed behaviors under normal and pathological conditions [121–125]. When recordedin vivo, dopaminergic midbrain neurons display either a single-spike, pacemaking pattern, burst or irregular firing [126–131], whilein vitrothe...