Experimental setup and pipeline for training and evaluation of a deep learning segmentation model. Top: experimental protocols, demarcation of AAR and infarcted tissue and manual labeling of transparent films. Middle: digitalization process (scans and digital images) and creating of labeled data sets fo...
Wilson [25] called them “ambiquitous proteins”, and was perhaps the first to present in a systematic way the idea that variation in intracellular distribution may represent a regulatory mechanism to suit changing metabolic needs. Burn [26] introduced the concept of “amphitropic proteins” to ...
Importantly, disturbance of the balance between the deleterious and the protective axis with the predominance of the ACE/Ang II/AT1R axis leads to many pathologies, including metabolic (diabetes mellitus), renal, cardiovascular (heart failure, myocardial infarction, hypertension), lung, hepatic, ...