Bafilomycin A1 (Baf-A1) is known as an inhibitor of late phase of autophagy by inhibiting fusion between autophagosomes and lysosomes as well as by inhibiting lysosomal degradation.Here we show that Baf-A1 of low concentration (1 nM) effectively and specifically inhibits and kills the pre-B ...
BafilomycinA1 (Baf) is amacrolideantibiotic drug that inhibits autophagy at the late stage. It functions as an inhibitor of vacuolar H(+)-ATPase (V-ATPase), which results in the inability of thelysosometo acidify.Ohtaet al. (1998)originally reported that Baf could induce apoptosis in a pancr...
Bafilomycin A1 属于大环内酯类抗生素,是一种 V-ATPase 抑制剂 (IC50=0.44 nM),具有特异性和可逆性。Bafilomycin A1 是自噬晚期阶段抑制剂,阻断自噬体与溶酶体的融合。Bafilomycin A1 也诱导凋亡。 规格价格库存数量 100 μg ¥ 648 现货 500 μg
Bafilomycin A1 prevents lysosomal cholesterol trafficking in macrophages and can be used to distinguish different types of ATPases. Research shows that Bafilomycin A1 can inhibit macroautophagy and promote apoptosis in colon cancer cells.A macrolide antibiotic and potent and selective inhibitor of vacuolar...
InvivoGen offers highly potent Bafilomycin A1, a specific V-ATPase inhibitor frequently used to study autophagy. Functionally validated using cellular assays.
Additionally, Bafilomycin A1 prevents lysosomal cholesterol trafficking in macrophages and can be used to distinguish different types of ATPases. Research shows that Bafilomycin A1 can inhibit macroautophagy and promote apoptosis in colon cancer cells.A macrolide antibiotic and potent and selective ...
inhibitor of vacuolar type H+-ATPase (V-ATPase). Selective for V-ATPase over other ATP hydrolyzing enzymes such as F-ATPases and the H+/K+-ATPase (P-ATPase). Lysosomal proton pump inhibitor. Autophagy inhibitor - either by blocking autophagosome-lysosome fusion or by blocking lysosomal ...
Bafilomycin A1, a specific inhibitor of vacuolar-type H( þ )-ATPase, blocks lysosomal cholesterol trafficking in macrophages. J. Biol. Chem. 268, 27345–27348 (1993). 33 Kinashi, H., Someno, K. & Sakaguchi, K. Isolation and characterization of concana- mycins A, B, and C. J. ...
Replaces Prod. #: ALX-380-030 Macrolide antibiotic that acts as a potent and selective inhibitor of vacuolar-type H+-ATPase (V-type) (IC50=004-0.4nmol/mg). Valuable tool for distinguishing among different types of ATPases. Inhibitor of endosomal acidification.¨Blocks lysosomal cholesterol ...
A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 500 pM). A valuable tool for distinguishing among different types of ATPases. Blocks lysosomal cholesterol trafficking in macrophages and is known to interfere with pH regulation in brain cells....