Bafilomycin A1, a specific inhibitor of H+-ATPases of the vacuolar type, was in the present study shown, at similar concentrations, to induce secretion of lysosomal enzyme and to elevate lysosomal pH in mouse macrophages. These results lend support to the previous suggestion of a triggering ...
Highly potent, selective inhibitor of vacuolar type H+-ATPase (V-ATPase). Selective for V-ATPase over other ATP hydrolyzing enzymes such as F-ATPases and the H+/K+-ATPase (P-ATPase). Lysosomal proton pump inhibitor. Autophagy inhibitor - either by blocking autophagosome-lysosome fusion or ...
Bafilomycin A1 (BafA1), a specific vacuolar H + ATPase (V-ATPase) inhibitor, is frequently used at high concentrations to block the fusion between autophagosomes and lysosomes and as an inhibitor of lysosomal degradation1,2. Acumulating evidence demonstrates that BafA1 suppresses the growth o...
Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, blocks lysosomal cholesterol trafficking in macrophages.| Furuchi, T., et al. 1993. J Biol Chem. 268: 27345-8. PMID: 8262974 Bafilomycin A1 (88899-55-2) 调制目标
BafilomycinA1 (Baf) is amacrolideantibiotic drug that inhibits autophagy at the late stage. It functions as an inhibitor of vacuolar H(+)-ATPase (V-ATPase), which results in the inability of thelysosometo acidify.Ohtaet al. (1998)originally reported that Baf could induce apoptosis in a pancr...
A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 500 pM). A valuable tool for distinguishing among different types of ATPases. Blocks lysosomal cholesterol trafficking in macrophages and is known to interfere with pH regulation in brain cells....
Additionally, Bafilomycin A1 prevents lysosomal cholesterol trafficking in macrophages and can be used to distinguish different types of ATPases. Research shows that Bafilomycin A1 can inhibit macroautophagy and promote apoptosis in colon cancer cells.A macrolide antibiotic and potent and selective ...
Bafilomycin A1, a specific inhibitor of vacuolar-type H( þ )-ATPase, blocks lysosomal cholesterol trafficking in macrophages. J. Biol. Chem. 268, 27345–27348 (1993). 33 Kinashi, H., Someno, K. & Sakaguchi, K. Isolation and characterization of concana- mycins A, B, and C. J. ...
Bafilomycin A1 属于大环内酯类抗生素,是一种 V-ATPase 抑制剂 (IC50=0.44 nM),具有特异性和可逆性。Bafilomycin A1 是自噬晚期阶段抑制剂,阻断自噬体与溶酶体的融合。Bafilomycin A1 也诱导凋亡。 规格价格库存数量 1 mg¥ 2,350现货 5 mg¥ 5,370现货 ...
Additionally, Bafilomycin A1 prevents lysosomal cholesterol trafficking in macrophages and can be used to distinguish different types of ATPases. Research shows that Bafilomycin A1 can inhibit macroautophagy and promote apoptosis in colon cancer cells.A macrolide antibiotic and potent and selective ...