These models are essential to generate predictions of exposure and safety for dosing regimens to be evaluated in a planned Phase 2 clinical trial.Clinical trial information: NCT03425279.ParametersADCMMAELinear Clearance (L/day)1.473.85Volume of Central Compartment (L)3.583.58*Vmax (mg/day)5.77-...
The event will feature Carl M. Gay, MD, PhD (MD Anderson Cancer Center), who will review the Phase 2 clinical trial data of mecbotamab vedotin (BA3011), a CAB-AXL-ADC, in refractory non-small cell lung cancer (NSCLC) and include a discussion of AXL as a contributor of therapeutic ...
A phase I trial of taxol given by a 6-hour intravenous infusion. Taxol is a unique mitotic inhibitor that has entered phase II investigation. Phase I studies demonstrated hypersensitivity reactions that were related to t... T Brown,K Havlin,G Weiss,... - 《Journal of Clinical Oncology ...