当地时间9月13日,新兴疗法(developmental therapeutics)优选口头报告(proffered paper)专场上展示了由中山大学肿瘤防治中心张力教授、赵洪云教授牵头发起的“YL201,一种新型B7H3靶向抗体药物偶联物(ADC),用于晚期实体瘤患者:来自首次人体Ⅰ期...
Detection of human B7-H3/CD276 by immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-B7-H3/CD276 (Product # A304-368A) (Lot 1) used at a dilution of 1:5,000 (0.2 µg/mL). Detection: DAB. Counterstain: IHC hematoxylin.View...
近期,中山大学肿瘤防治中心张力、赵洪云教授团队在Nature Medicine(IF:82.9)发表文章A B7H3-targeting antibody–drug conjugate in advanced solid tumors: a phase 1/1b trial,公布了全球首个B7H3靶向ADC药物YL201治疗晚期实体瘤的I期临...
当地时间9月13日,新兴疗法(developmentaltherapeutics)优选口头报告(proffered paper)专场上展示了由中山大学肿瘤防治中心张力教授、赵洪云教授牵头发起的“YL201,一种新型B7H3靶向抗体药物偶联物(ADC),用于晚期实体瘤患者:来自首次人体Ⅰ期研究的结果[YL201, a novel B7H3-targeting antibody-drug conjugate (ADC), in...
Applications Reported:The M3.2D7 antibody has been reported for use in flow cytometric analysis. Applications Tested: Has been tested by flow cytometric analysis of mouse B7-H3 transfected cells. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount...
CD276 (B7-H3) Antibody (17-2769-42) in Flow Staining of normal human monocyte-derived dendritic cells with Mouse IgG1 K Isotype Control APC (Product # 17-4714-81) (blue histogram) or Anti-Human CD276 APC (purple histogram). Total viable cells were used for analysis.View more ...
1.B7-3 targetedantibody-based immunotherapy of malignant diseases. Expert Opin Biol Ther. 2020Dec 21;1-16. 2.B7-H3 role in theimmune landscape of cancer. Am J Clin Exp Immunol. 2017; 6(4): 66–75. 3.NK-Cell-MediatedTargeting of Various Solid Tumors Using a B7-H3 Tri-Specific Killer...
B7-H3和B7-H4是I型跨膜蛋白,属于B7家族成员,它们的异常与很多疾病相关,如结肠癌、乳腺癌、肝癌和肺癌等,已成为新的免疫治疗靶点。 但到目前为止,还没有FDA批准的靶向B7-H3和B7-H4的治疗或药物,人们探索了不同的抗B7-H3和B7-H4的方法,包括单克隆抗体(mAb)、抗体依赖性细胞介导的细胞毒性(ADCC)、CAR-T疗法...
1.B7-3 targetedantibody-based immunotherapy of malignant diseases. Expert Opin Biol Ther. 2020Dec 21;1-16. 2.B7-H3 role in theimmune landscape of cancer. Am J Clin Exp Immunol. 2017; 6(4): 66–75. 3.NK-Cell-MediatedTargeting of Various Solid Tumors Using...
MacroGenics 公司还通过将 B7-H3 抗体与化学基团vc-seco-DUBA 连接,构建了靶向 B7-H3 的抗体偶联药物(antibody conjugated drug,ADC)MGC018,MGC018 不仅对表达 B7-H3 的癌细胞有杀伤作用,由于其具有易被蛋白酶降解的连接肽,其对癌症...