Comparative “ome”-based profilings of untreated and MSA-treated melanoma cells linked the anti-oxidative response system with MHC class I antigen processing. Since MSA treatment enhanced MHC class I surface expression also on different human tumors cell lines, MSA might affect the malignant ...
Similarly, reduction of tumor growth in vivo required both high tumor antigen expression and transfer of high avidity neoantigen- or TAA-reactive CD8+ T cells. Conclusions To conclude, we have created a novel model of neoantigen- and TAA-reactive ACT in immunotherapy-refractory B16F10 melanoma. ...
In anti-melanomas compounds, we have demonstrated that alternol could decrease the expression levels of cyclin-dependent kinase 2 (CDK2) and proliferating cell nuclear antigen (PCNA), and activate CDK inhibitor1A (p21) to inhibit melanoma B16F0 cell proliferation5. Moreover, alternol increases ...
A simple technique for preservation of fixation-sensitive antigens in paraffin-embedded tissues J Histochem Cytochem, 42 (1994), pp. 1127-1134 CrossrefView in ScopusGoogle Scholar Brunda et al., 1993 M.J. Brunda, L. Luistro, R.R. Warrier, et al. Antitumor and antimetastatic activity of ...
One of the factors contributing to the inefficiency of the cancer immunity cycle is the release of an insufficient amount of tumor antigens from tumor cells to prime and activate T cells and initiate the cancer immunity cycle [6]. To reinforce this step, our group has focused on the ...
The vascular endothelial growth factor receptor-2 (VEGFR-2) plays an important role in melanoma development and progression. Peptide vaccines have shown great potential in cancer immunotherapy by targeting VEGFR-2 as a tumor-ass...
Tyrosinase-related protein-1 or gp75 (TYRP-1/gp75) antigen is a melanosomal polypeptide. It is the most abundant glycoprotein synthesized by pigmented melanocytes and melanomas. It is specific for melanocytes and both primary and metastatic melanomas. In mice, administration of the mouse mAb ...
E.; Martínez-Pomares, L.; Ortiz-Quintero, J.; Lavandero, S.; et al. TLR4, but Neither Dectin-1 nor Dectin-2, Participates in the Mollusk Hemocyanin-Induced Proinflammatory Effects in Antigen-Presenting Cells from Mammals.Front Immunol.2019,10, 1136. [Google Scholar] [CrossRef] [PubMed]...
FBA; ALDO-A; Fructose 1,6 Bisphosphate Aldolase; Lung cancer antigen NY-LU-1; Muscle-type aldolase来源:原核表达宿主:E.coli内毒素水平:<1.0EU/µg(LAL法测定)亚细胞定位:分泌预测分子量:31.4kDa实际分子量:31kDa(差异分析请参阅说明书)片段与标签:Asp18~Gly273 with N-terminal His Tag缓冲...
Consistent with this, following adoptive transfer of tumor antigen-specific CD8 T cells into tumor-bearing Rag1(-/-) mice, dual-module adenovirus significantly enhanced CD8 T cell-mediated tumor rejection. In addition, secondary tumor challenge at a distal site was completely suppressed in mice ...