B-cell Acute lymphoblastic leukemiahematological profilebiochemical profileB-cell acute lymphoblastic leukemia is the most common type of leukemia found in children. Timely diagnosis, white blood cell count, age of onset, and sex are considered the most important prognostic factors in childhood leukemia...
Therefore, COVID-19 infection raises the risk of stroke in children with acute lymphoblastic leukemia (ALL) owing to their immunodeficiency and hypercoagulability. We present the case of a 6-year-old girl with pre-B-cell ALL who was hospitalized with the diagnosis of COVID-19 and experi- ...
G. The genomic landscape of acute lymphoblastic leukemia in children and young adults. Hematol. Am. Soc. Hematol. Educ. Program. 2014, 174–180 (2014). Article Google Scholar UK Childhood Cancer Study Investigators. The United Kingdom Childhood Cancer Study: objectives, materials and methods. ...
Precursor B-cell acute lymphoblastic leukemia (B-ALL) is the most common cancers in children. Failure of induction chemotherapy is a major factor leading to relapse and death in children with B-ALL. Given the importance of altered metabolites in the carcinogenesis of pediatric B-ALL, studying th...
B-cell acute lymphoblastic leukemia (B-ALL) is the most common type of cancer found in children. Although the overall survival rates are now >80%, 15%–20% of pediatric patients relapse, with survival rates subsequently dropping to 5%–10%. Cmpd10357, 3-amino-5-arylamino-6-chloro-N- (...
Acute lymphoblastic leukemia(ALL) is the most common type of childhood cancer, with approximately 6000 new cases diagnosed in the United States each year (Siegel et al., 2014). Most leukemias originate within the B cell rather than the Tcell lineage(Hunger and Mullighan, 2015;Inaba et al.,...
PurposeAcute lymphoblastic leukemia (ALL) can occur across all age groups, with a strikingly higher cure rate in children compared with adults. However, the pharmacological basis of age-related differences in ALL treatment response remains unclear.MethodsStudying 767 children and 309 adults with newly...
There is increasing evidence for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children. To identify new risk variants for B-cell ALL (B-ALL) we conducted a meta-analysis with four GWAS (genome-wide ass
Integration of next-generation sequencing to treat acute lymphoblastic leukemia with targetable lesions: the St. Jude Children’s Research Hospital approach. Front Pediatr. 2017;5:258. Yeoh AEJ, Lu Y, Chin WHN, Chiew EKH, Lim EH, Li Z, et al. Intensifying treatment of childhood B-...
The prerequisite to prevent childhood B-cell acute lymphoblastic leukemia (B-ALL) is to decipher its etiology. The current model suggests that infection triggers B-ALL development through induction of activation-induced cytidine deaminase (AID; also known as AICDA) in precursor B-cells. This eviden...