Tob38-depleted mitochondria are deficient in the import of β-barrel precursor proteins, but not of other outer membrane proteins or proteins of other mitochondrial subcompartments. We conclude that Tob38 has a crucial function in the biogenesis of β-barrel proteins of mitochondria.EMBO reports...
Furthermore, a b-hairpin motif from mitochondrial proteins targets chloroplast b-barrel proteins to mitochondria. The mitochondrial targeting depends on the hydrophobicity of the b-hairpin motif. Finally, this motif interacts with the mitochondrial import receptor Tom20. Collectively, we reveal that b-...
Four of the other five proteins are annotated as non-mitochondrial proteins and have sequence similarity to known functional domains. Thus, in this study, we chose to focus on the remaining protein EHI_178630 (Uniprot accession C4LUS8), which attained the second highest predictor score, second ...
Changes in its permeability, induced by voltage or apoptosis-related proteins, have been implicated in apoptotic pathways. The three-dimensional structure of VDAC has recently been determined as a 19-stranded b-barrel with an in-lying N-terminal helix. However, its gating mechanism is still ...
Roles of the Mdm10, Tom7, Mdm12, and Mmm1 Proteins in the Assembly of Mitochondrial Outer Membrane Proteins in Neurospora crassa Mdm10, Mdm12, and Mmm1 are implicated in several mitochondrial functions. We show that loss of any of these proteins in Neurospora crassa results in the fo......
The Lol system, comprising five Lol proteins, transfers lipoproteins from the inner to the outer membrane of Escherichia coli. Periplasmic LolA accepts lipoproteins from LolCDE in the inner membrane and immediately transfers them to LolB, a receptor anchored to the outer membrane. The unclosed β-...
coli. BAM promotes the folding and insertion of b-barrel proteins into the outer membrane via a poorly understood mechanism. Several current models suggest that BAM functions through a 'lateral gating' motion of the b-barrel of BamA. Here we present a cryo-EM structure of the BamABCDE ...
Using acrylamide quenching measurements, we examined the accessibility of the indole ring, to probe for possible variations in the local Trp environment of the three proteins. Our data (Fig. 1c) indicates that W42 (W149F mutant) undergoes an increase in indole solvent accessibility with ...
This chapter discusses the regulation of synthesis and transport of secreted proteins in cereal aleurone. It is one of the few digestive tissues found in p... RL Jones,JV Jacobsen - 《International Review of Cytology-a Survey of Cell Biology》 被引量: 474发表: 1991年 Comparison of the domai...
FhuA, the receptor for ferrichrome-iron in Escherichia coli, is a member of a family of integral outer membrane proteins, which, together with the energy-t... Ferguson,AD,Hofmann,E,Coulton,JW,... - 《Science》 被引量: 1518发表: 1998年 FhuA Barrel-Cork Hybrids Are Active Transporters ...