Antibodies are produced by B lymphocytes. Upon binding of antigen to membrane immunoglobulin (mIg), the B lymphocyte becomes activated and differentiates into an antibody producing plasmacell. mIg is the antigen recognition unit of the B cell receptor complex, in which Iga and Igb proteins are ...
10. In most studies, the presence of infiltrated B lymphocytes was determined by IHC of pan-B cell markers such as CD20. We hypothesized that distinct infiltrated B cell clusters might have diverse functions in tumor immunology and that the combinational transcriptional signature ...
Jamieson, A.M. et al. The role of the NKG2D immunoreceptor in immune cell activation and natural killing. Raff, M.C. Role of thymus-derived lymphocytes in the secondary humoral immune response in mice.Nature226 Bour, H. et al. Major histocompatibility complex class I-restricted CD8+T cells...
review, we will describe the current understanding of the role of tumour-infiltrating B lymphocytes in NSCLC, discuss their prognostic significance, their functionality within the tumour microenvironment and ultimately how we might harness B-cell biology to develop B-cell therapeutic strategies in cancer...
1. Heather E, Machado., Emily, Mitchell., Nina F, Øbro., Kirsten, Kübler., Megan, Davies., Daniel, et al.(2022). Diverse mutational landscapes in human lymphocytes.Nature, 608(7924), 0. doi:10.1038/s41586-022-05072-7 2. Aude, Magerus-Chatinet., Bénédicte, Neven., Marie-Claud...
5. Shoukat, Afshar-Sterle., Dimitra, Zotos., Nicholas J, Bernard., Anna K, Scherger., Lisa, Rödling., et al.(2014). Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous...
摘要: Bone Marrow Transplantation is a high quality, peer-reviewed journal covering all aspects of clinical and basic haemopoietic stem cell transplantation.关键词: B-cell leukemia (BCL1) murine lymphokine activated killer cells (LAK cells) immunity ...
B Lymphocytes B lymphocytes exist as different subsets, the majority belonging to the recirculating pool of follicular “B2” B cells, but in addition there are the T cell independent“B1” and marginal zone B cell subsets. The best-characterized B cell lectin is CD22/Siglec-2 which functions...
Immunity LI Yiye,LUShengdong National Laboratoryof MedicalMolecular Biology,Instituteof BasicMedicalSciences,Chinese Academyof Medical Sciences,Schoolof Basic Medicine,Peking UnionMedical College,Beijing, 100005,China 【Abstract】Lymphocytes—mediatedcytotoxicity ...
regarding the role of the B cell receptor in this cell fate decision and a clearer picture has also emerged regarding the anatomical location of ligands for Notch2 in the spleen. This cell fate decision could provide mechanistic insights that are relevant to other commitment events in lymphocytes...