B-lymphoblastic lymphoma (B-LBL)/leukemia is a neoplasm of immature lymphoid cells (lymphoblasts) committed to the B-cell lineage. While most patients present with predominant blood and bone marrow involvement, better known as B acute lymphoblastic leukemia (B-ALL), a subset of patients present...
[8]Ting S, Mixue X, Lixia Z, et al. T315I mutation exerts a dismal prognosis on adult BCR-ABL1-positive acute lymphoblastic leukemia, and salvage therapy with ponatinib or CAR-T cell and bridging to allogeneic hematopoietic st...
2024年8月,蒙国宇教授团队在《International Journal of Biological Sciences》【IF8.2,Q1】期刊在线发表题为“Integrative alternative splicing analysis reveals new prognosis signature in B-cell acute lymphoblastic leukemia.”——综合可变剪...
[8]Ting S, Mixue X, Lixia Z, et al. T315I mutation exerts a dismal prognosis on adult BCR-ABL1-positive acute lymphoblastic leukemia, and salvage therapy with ponatinib or CAR-T cell and bridging to allogeneic hematopoietic stem cell transplantation can improve clinical outcomes. ...
Acute lymphoblastic leukemia(ALL) is the most common type of childhood cancer, with approximately 6000 new cases diagnosed in the United States each year (Siegel et al., 2014). Most leukemias originate within the B cell rather than the Tcell lineage(Hunger and Mullighan, 2015;Inaba et al.,...
B-acute lymphoblastic leukemia/lymphoblastic lymphoma.B-acute lymphoblastic leukemia/lymphoblastic lymphoma.doi:10.1309/AJCPAN7BH5DNYWZBB-ALLCytogeneticsFlowcytometryimmunophenotypingMyeloidThis session of the 2013 Society of Hematopathology/European Association for Haematopathology Workshop was dedicated to B-acut...
为了攻克这个难题,中国人民解放军西部战区总医院血液科等单位的研究人员在《Heliyon》期刊上发表了一篇名为《Rapid development of acute monocytic leukemia (AML-M5b) with t (9;11)(p22;q23) after chemotherapy for T-cell lymphoblastic lymphoma: A case report》的论文。他们通过研究发现,T-LBL 进展为 AML...
(hyperdiploidy or hypodiploidy, respectively). This first genetic insult is the major determinant for the prognosis and therapeutic outcome of patients. B cell leukaemia in adults displays similar molecular features as its paediatric counterpart. However, since this disease is highly represented in the...
前B淋巴细胞白血病（Precursor B-cell Acute Lymphoblastic Leukemia，B-ALL）是一种起源于骨髓中未成熟前体B淋巴细胞的急性白血病，属于急性淋巴细胞白血病（ALL）的主要亚型（占ALL的80-85%）。 - 细胞来源：B细胞发育早期阶段（前B细胞），停滞在原始或幼稚阶段。 - 特征：骨髓中大量原始/幼稚淋巴细胞增殖，...
Mullighan CG, Su X, Zhang J, et al. Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med 2009;360:470-480; Stanulla M, Dagdan E,Zaliova M, et al. IKZF1plus defines a new minimal residual disease-dependent very-poor prognostic profile in pediatric B-cell...