20 一,概述 慢性淋巴细胞白血病(Chronic lymphocytic leukemia, CLL)是一种具有特定免疫表型特征的成熟 B 淋巴细胞克隆 增殖性肿瘤,以淋巴细胞在外周血,骨髓,脾脏和淋巴结聚 集为特征,目前仍为不可治愈的疾病.该疾病主要发生在中 老年人群,中位发病年龄超过 70 周岁[1,2],随着社会老龄化 程度加深,慢性淋巴细胞...
B幼淋巴细胞白血病(B cell prolymphocytic leukemia, B-PLL)是一种非常罕见的B细胞肿瘤,由幼淋巴细胞组成,通常累及外周血、骨髓和脾脏。实际上,“幼淋巴细胞”这个名称并不恰当,因为B-PLL肿瘤细胞是成熟的活化B细胞。根据定义,这些幼淋巴细胞在血液和骨髓细胞中占比超过55%。
At the indolent end of the spectrum is monoclonal B-cell lymphocytosis, which can be a normal finding in older individuals or show a low rate of progression to chronic lymphocytic leukemia. At the other end, aggressive lymphomas such as high-grade B-cell lymphoma may involve the blood in ...
8. Badar T , Szabo A , Wadleigh M, et al. Real‐world outcomes of adult B-cell acute lymphocytic leukemia patients treated withinotuzumab ozogamicin[J]. Clin Lymphoma Myeloma Leuk, 2020, 20(8):556‐560.e2. DOI:10.1016...
including mantle cell lymphoma (MCL), follicular lymphoma (FL), diffuse large B cell lymphoma (DLBCL), Burkitt lymphoma (BL), and chronic lymphocytic leukemia (CLL), which also derives from mature B cells. Emphasis is given to the mechanisms of genetic lesion and the nature of the involved ...
B-cell chronic lymphocytic leukemia (B-CLL) is the most frequent type of leukemia among adults in the Western world, with an incidence of about 5 cases per 100,000 residents annually (1,2). The disease affects mainly people of advanced age, but about 20% of patients are younger than 55...
4) B cell chronic lymphocytic leukemia B细胞慢性淋巴细胞白血病 例句>> 5) B-lineage Leukemia B淋巴细胞性白血病6) B-ALL 急性B淋巴细胞白血病 1. Analysis of immunophenotypic modulation in childhood B-ALL with positive minimal residual disease and the clinical analysis of prognosis; 小儿急性B...
Advances in the biology and treatment of B-cell chronic lymphocytic leukemia Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in the western hemisphere. Diagnosis and staging of CLL are usually straightforward,... S O'Brien,AD Giglio,M Keating - 《Blood》 被引量: 354发...
参考文献[1] Jia, et al. The global pipeline of cell therapies for cancer. News &Analysis.[2] James R. Berenson, MD. Role of Serum B-cell Maturation Antigen (sBCMA)in Predicting Outcomes and Monitoring for Multiple Myeloma and ChronicLymphocytic Leukemia Patients. 2019.[3] Angela Dispenzier...
The cellular biology of B-cell chronic lymphocytic leukemia. In conclusion, B-CLL cells through their immunophenotype have the functional potential required to interact with cells in what has been called the immunolo... J Jurlander - 《Critical Reviews in Oncology/hematology》...