33 CII-immunized mice received 2 intraperitoneal injections (days 5 and 10) with CD22/cal or control GG5/cal (160 μg/kg/injection). The paws were evaluated for clinical arthritis and each paw was individually scored using a 4-point scale: 0, normal paw; 1, minimal swelling or redness...
Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. Biochemistry 20, 2361–70 (1981). Article CAS Google Scholar Clackson, T., Hoogenboom, H. R., Griffiths, A. D. & ...
In view of the frequency and duration of injection, we completed 21 injections within 3.5 months, including two weeks for behavioral tests to eliminate B cells, compared to 3–6 injections within 2 months in their research, and our design maintained consecutively adequate depletion of B cells in...
Deficiency of complement in humans and mice is associated with the development of lupus and with abnormal repair of inflammatory and immune complex-mediate... PK Potter,J. Cortes-hernandez,P Quartier,... - 《Journal of Immunology》 被引量: 490发表: 2003年 Systemic immunological effects of cytok...
2001. Efficacy and safety of a stan- dardised 500 unit dose of Dysport (clostridium botulinum toxin type A haemaglutinin complex) in a heterogeneous ... J Wissel,P Kaňovský,E Růžička,... - 《Antioxidants & Redox Signaling》 被引量: 49发表: 2012年 Pericranial injection of botu...
[43]. In a phase IIa clinical trial, single intravenous injections of Arrowhead’s first candidate drug ARC-520 resulted in dose-dependent reductions in HBsAg; a single dose of 2 mg/kg resulted in HBsAg reduction of up to 50%, with significant reductions maintained for 43–57 days [44]....
Of note, CLDN12 and FABP5 were among the genes identified in IPA as being modulated by upstream IL1B and NFkB complex activity (Figure 4c). Figure 6. Psoriasis mast cells share half of their differentially expressed genes with whole skin, while mast cells and neuronal signatures are ...
Injections of interferon and oral nucleoside analogs are used to treat persistent HBV infection [4]. Currently, HIV and HBV polymerase reverse transcriptase inhibitors are licensed treatments for HBV, and only 30–40% of individuals with chronic HBV (CHB) react to interferon therapy [4]. The ...
Rare Disease Day, observed annually on the last day of February, is the official awareness-raising campaign for rare diseases. Never giving up In 2009, Niuniu was diagnosed on the 52nd day after birth with Tuberous Scler...
Three rabbit antisera are described which are specific without absorption (titer 1:100) for separated human B cells, as measured by complement and non-complement fixing assays. The method of production of these sera involved injections o... KI Welsh,MJ Turner - 《Tissue Antigens》 被引量: 11...