1. 初始B细胞(Naive B cells) 特征: 未接触过抗原。 表面表达未经历体细胞超突变的IgM和IgD抗体(B细胞受体,BCR)。 功能: 在遇到抗原后,通过活化、增殖和分化产生效应B细胞或记忆B细胞。 2. 效应B细胞(Effector B cells, Plasma cells) 特征: 由初始B细胞活化分化而来。丢失了表面BCR,专注于分泌抗体。 功能...
衰老/自身免疫相关B细胞(Age/autoimmunity-associated B cells,ABCs)是一种随年龄增加而扩增的B细胞亚群(在部分疾病中与年龄无关),2011年首次在小鼠中被发现可能是自身免疫疾病的潜在驱动因素。 其特征为表达传统上与T细胞相关的转录因子T-bet (Tbx21),表面标志物为CD21lowT-b...
参考文献 1.Petitprez F, de Reyniès A, Keung EZ,et al. B cells are associated with survival and immunotherapy response in sarcomma[J].Nature, 2020,577(7791):556-560. 2.Helmink BA, Reddy SM, Gao J,et al. B cells and tertiary lymphoid structures promote immunotherapy response[J]. Nat...
B cells are a subtype of lymphocyte. They form part of the adaptive immune response and mediate humoral immunity. B cells can produce high-affinity antibodies and generate immunological memory. Related Subjects B-1 cells B-2 cells B-cell receptor Follicular B cells Marginal zone B cells ...
[7]Mielle J,Tison A,Cornec D,et al.B cells in Sjögren's syndrome:from pathophysiology to therapeutic target[J].Rheumatology (Oxford),2019.doi: 10.1093/rheumatology/key332. [8]Kroese FG,Abdulahad WH,Haacke E,et al.B-cell hyperactivity in primary Sjögren's syndrome[J]. Expert Rev ...
在人体免疫系统中,记忆B细胞(memory B cells,特指那些已发生类别转换并表达CD27标记的B细胞)的数量普遍超过外周血中的初始B细胞,尤以老年人群为甚。这一发现,加之记忆B细胞所展现出的显著稳定性(可维持至少数十年之久)及其在体外实验中相较于初始B细胞更为迅速的激活动力学特性,引发了学界对其功能的深入思考。
英文标题:Single-cell landscape and clinical outcomes of infiltrating B cells in colorectal cancer 中文标题:在结直肠癌中B细胞单细胞图谱及临床情况 期刊:《Immunology》 发表时间: 14 August 2022 数据:GSE132465,GSE146771,TCGA-COAD 文献链接:https://doi.org/10.1111/imm.13568](https://doi.org/10.1111/...
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B cells, plasma cells and antibody repertoires in the tumour microenvironment. Nat Rev Immunol. 2020 May;20(5):294-307. 3. Barnas JL, etc. B cell targeted therapies in autoimmune disease. Curr Opin Immunol. 2019 Dec;61:92-99. 发布于 2023-04-19 10:35・IP 属地北京...
近日,复旦大学附属中山医院樊嘉院士、高强教授、中国科学院上海免疫与感染研究所张晓明研究员、浙江大学基础医学院郭国骥教授团队合作,在《Science》 期刊发表了题为“A blueprint for tumor-infiltrating B cells across human cancers ”的研究论文。该研究结合单细胞转录组、单细胞BCR和单细胞ATAC的多组学数据,系统性刻...